Mechanochemical Friedel–Crafts acylations

Đud, Mateja; Briš, Anamarija; Jušinski, Iva; Gracin, Davor; Margetić, Davor

doi:10.3762/bjoc.15.130

Pregled bibliografske jedinice broj: 1007981

Mechanochemical Friedel–Crafts acylations

Đud, Mateja; Briš, Anamarija; Jušinski, Iva; Gracin, Davor; Margetić, Davor

Mechanochemical Friedel–Crafts acylations // Beilstein journal of organic chemistry, 15 (2019), 1313-1320 doi:10.3762/bjoc.15.130 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1007981 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mechanochemical Friedel–Crafts acylations

Autori
Đud, Mateja ; Briš, Anamarija ; Jušinski, Iva ; Gracin, Davor ; Margetić, Davor

Izvornik
Beilstein journal of organic chemistry (2195-951X) 15 (2019); 1313-1320

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ball milling ; Friedel–Crafts reaction ; mechanochemistry

Sažetak
Friedel–Crafts (FC) acylation reactions were exploited in the preparation of ketone- functionalized aromatics. Environmentally more friendly, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents and milling support were studied to establish the optimal reaction conditions. The scope of the reaction was explored by employment of different aromatic hydrocarbons in conjunction with anhydrides and acylation reagents. It was shown that certain FC-reactive aromatics could be effectively functionalized by FC acylations carried out under ball-milling conditions without the presence of a solvent. The reaction mechanism was studied by in situ Raman and ex situ IR spectroscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Projekti:
HRZZ-IP-2013-11-9310 - Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula (NoncoPhoto) (Margetić, Davor, HRZZ - 2013-11) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Davor Gracin (autor)