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Pregled bibliografske jedinice broj: 1007598

Bone morphogenetic proteins in fracture repair


Dumić-Čule, Ivo; Perić, Mihaela; Kučko, Lucija; Grgurević, Lovorka; Pećina, Marko; Vukičević, Slobodan
Bone morphogenetic proteins in fracture repair // International orthopaedics, 42 (2018), 11; 2619-2626 doi:10.1007/s00264-018-4153-y (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1007598 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone morphogenetic proteins in fracture repair

Autori
Dumić-Čule, Ivo ; Perić, Mihaela ; Kučko, Lucija ; Grgurević, Lovorka ; Pećina, Marko ; Vukičević, Slobodan

Izvornik
International orthopaedics (0341-2695) 42 (2018), 11; 2619-2626

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
bone ; bone fracture ; bone morphogenetic proteins ; regenerative treatment BMP6 containing osteogenic device

Sažetak
Bone fractures represent a significant medical morbidity among aged population with osteoporosis. Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. Though BMP-mediated fracture healing has been well-documented in preclinical models, there has been no clinical study that demonstrated unequivocally that indeed a BMP when presented with an appropriate scaffold could provide basis for robust outcome for delayed or non-union diaphyseal bone fractures. This review presents a comprehensive insight towards the existing knowledge on the role of BMP signaling in bone formation and maintenance. Also therapeutic options based on BMP biology are discussed.A novel osteoinductive autologous bone graft substitute (ABGS) aimed to accelerate bone regeneration was developed and is currently being tested in the clinical setting. It comprises of a biologically compatible autologous carrier made from the patient's peripheral blood (autologous blood coagulum, ABC) and of rhBMP6 as an active ingredient. Such formulation circumvents the use of animal-derived materials, significantly limits inflammatory processes common in commercial bone devices and renders the carrier flexible, malleable, and injectable ensuring the ease of use. The ongoing clinical trials result will provide more detailed insights into the safety, tolerability, pharmacokinetics, and bone healing effects in humans and potentially provide novel and safe therapeutic options for bone repair.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi doi.org link.springer.com

Citiraj ovu publikaciju:

Dumić-Čule, Ivo; Perić, Mihaela; Kučko, Lucija; Grgurević, Lovorka; Pećina, Marko; Vukičević, Slobodan
Bone morphogenetic proteins in fracture repair // International orthopaedics, 42 (2018), 11; 2619-2626 doi:10.1007/s00264-018-4153-y (međunarodna recenzija, pregledni rad, znanstveni)
Dumić-Čule, I., Perić, M., Kučko, L., Grgurević, L., Pećina, M. & Vukičević, S. (2018) Bone morphogenetic proteins in fracture repair. International orthopaedics, 42 (11), 2619-2626 doi:10.1007/s00264-018-4153-y.
@article{article, author = {Dumi\'{c}-\v{C}ule, Ivo and Peri\'{c}, Mihaela and Ku\v{c}ko, Lucija and Grgurevi\'{c}, Lovorka and Pe\'{c}ina, Marko and Vuki\v{c}evi\'{c}, Slobodan}, year = {2018}, pages = {2619-2626}, DOI = {10.1007/s00264-018-4153-y}, keywords = {bone, bone fracture, bone morphogenetic proteins, regenerative treatment BMP6 containing osteogenic device}, journal = {International orthopaedics}, doi = {10.1007/s00264-018-4153-y}, volume = {42}, number = {11}, issn = {0341-2695}, title = {Bone morphogenetic proteins in fracture repair}, keyword = {bone, bone fracture, bone morphogenetic proteins, regenerative treatment BMP6 containing osteogenic device} }
@article{article, author = {Dumi\'{c}-\v{C}ule, Ivo and Peri\'{c}, Mihaela and Ku\v{c}ko, Lucija and Grgurevi\'{c}, Lovorka and Pe\'{c}ina, Marko and Vuki\v{c}evi\'{c}, Slobodan}, year = {2018}, pages = {2619-2626}, DOI = {10.1007/s00264-018-4153-y}, keywords = {bone, bone fracture, bone morphogenetic proteins, regenerative treatment BMP6 containing osteogenic device}, journal = {International orthopaedics}, doi = {10.1007/s00264-018-4153-y}, volume = {42}, number = {11}, issn = {0341-2695}, title = {Bone morphogenetic proteins in fracture repair}, keyword = {bone, bone fracture, bone morphogenetic proteins, regenerative treatment BMP6 containing osteogenic device} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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