Pregled bibliografske jedinice broj: 1007598
Bone morphogenetic proteins in fracture repair
Bone morphogenetic proteins in fracture repair // International orthopaedics, 42 (2018), 11; 2619-2626 doi:10.1007/s00264-018-4153-y (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1007598 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Bone morphogenetic proteins in fracture repair
Autori
Dumić-Čule, Ivo ; Perić, Mihaela ; Kučko, Lucija ; Grgurević, Lovorka ; Pećina, Marko ; Vukičević, Slobodan
Izvornik
International orthopaedics (0341-2695) 42
(2018), 11;
2619-2626
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
bone ; bone fracture ; bone morphogenetic proteins ; regenerative treatment BMP6 containing osteogenic device
Sažetak
Bone fractures represent a significant medical morbidity among aged population with osteoporosis. Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. Though BMP-mediated fracture healing has been well-documented in preclinical models, there has been no clinical study that demonstrated unequivocally that indeed a BMP when presented with an appropriate scaffold could provide basis for robust outcome for delayed or non-union diaphyseal bone fractures. This review presents a comprehensive insight towards the existing knowledge on the role of BMP signaling in bone formation and maintenance. Also therapeutic options based on BMP biology are discussed.A novel osteoinductive autologous bone graft substitute (ABGS) aimed to accelerate bone regeneration was developed and is currently being tested in the clinical setting. It comprises of a biologically compatible autologous carrier made from the patient's peripheral blood (autologous blood coagulum, ABC) and of rhBMP6 as an active ingredient. Such formulation circumvents the use of animal-derived materials, significantly limits inflammatory processes common in commercial bone devices and renders the carrier flexible, malleable, and injectable ensuring the ease of use. The ongoing clinical trials result will provide more detailed insights into the safety, tolerability, pharmacokinetics, and bone healing effects in humans and potentially provide novel and safe therapeutic options for bone repair.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Slobodan Vukičević
(autor)
Marko Pećina
(autor)
Mihaela Perić
(autor)
Ivo Dumić-Čule
(autor)
Lovorka Grgurević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE