Naslov
Spray-dried nanoparticle-loaded microspheres for dexamethasone nasal delivery

Autori
Jurišić Dukovski, Bisera ; Mrak, Lea ; Filipović- Grčić, Jelena ; Lovrić, Jasmina ; Hafner, Anita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Future Medicines For One World / - , 2017

Skup
6th FIP Pharmaceutical Sciences World Congress

Mjesto i datum
Stockholm, Švedska, 21.05.2017. - 24.05.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
spray-dry, dexamethasone, pectin, lipid/alginate nanoparticles

Sažetak
Backgrounds Nasal administration of corticosteroids is a natural choice for the treatment of chronic rhinosinusitis with nasal polyps. Aims Focus is on the development of delivery systems that could improve efficiency and safety of nasal corticosteroid administration through delivery to the polyp site, prolonged residence time at the nasal mucosa and moderated pharmacokinetic profile. Methods Dexamethasone (Dex)-loaded lipid/alginate nanoparticles were obtained by injection of ethanolic lipid/Dex solution into aqueous alginate solution. The non-entrapped Dex was separated by filtration. Nanoparticles were characterized in terms of size, zeta-potential (Zetasizer 3000 HS, Malvern) and Dex content (UPLC, Agilent Infinity 1290). Nanoparticle suspension in pectin continuous phase was subjected to spray drying (Büchi 190). Spray- dried microspheres were characterized in terms of particle size (Olympus BH-2), zeta potential, Dex content and swelling behavior. Results Nanoparticles with mean diameter of 280 nm, polydispersity index of 0.229 and zeta- potential of -35.1 mV were obtained. Spray- dried microspheres were characterized by diameter of 3.83 mm, zeta-potential of -38.0 mV, drug loading of 3.0% (production yield 44.8%) and swelling behavior controlled by Ca2+ crosslinking (simulated nasal fluid (Ca2+ conc. 5.3 mM) and water uptake of 40 and 98 ml/mg, respectively). Summary/Conclusion This study shows the potential of nanoparticle- loaded microspheres to act as a Dex nasal delivery platform. Controlled swelling behavior is a prerequisite for the prolonged residence time and Dex release at the nasal mucosa. Such properties could improve the local therapeutic effect and minimize the possibility for adverse effects.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA