Naslov
Age and sex dependence of total and ionized serum calcium concentration

Autori
Has-Schön, Elizabeta ; Majetić-Cetina, N ; Has, Borislav ; Bučević, Brankica ; Wagner, Jadranka

Izvornik
Periodicum biologorum (0031-5362) 101 (1999), 3; 211-214

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ionized calcium; total calcium; age; osteoporosis

Sažetak
Total and ionized serum calcium concentration was measured in healthy volunteers, males (87) and females (88), averaged 36 years. Mean values obtained were 2, 456 ± ; ; ; 0, 151 for total, and 1, 219 ± ; ; ; 0, 056 mmolL-1 for ionized calcium. A significanr negative linear correlation (p<0, 001) of both, total and ionized serum calcium with age was proved, stronger for total than ionized calcium, and greater in females than in males. Total calcium relationship with age had an almost linear trend, while ionized calcium and age followed a polynomial curve, with a constant Ca 2+ concentration in the first 40 years of life, and dropping after the age of 40. When divided into three age groups (0-25, 26-50 and >50), a significant difference of mean values between all age groups was shown for total calcium, reaching over 10% in females (p<0, 001). For ionized calcium, no difference was found between the first two age groups, while difference was significant if compared oldest with younger age group, reaching 6% in females(p<0, 001). Also, a definite correlation of the two calcium forms in serum was confirmed (p<0, 001), slightly stronger in females than in males. The variabilty of the serum concentrations of both calcium forms was shown to be greater in older persons, more distinctive in females than in males (88% for Ca_2+ and 57% for Ca_t). Our results indicate that the regulation of calcium serum concentration is disrupted after the age of 40, more in women than in men. In persons after age of 40, Ca_2+ serum concentration is a better indicator of general calcium homeostasis than Ca_t.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA