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Pregled bibliografske jedinice broj: 1006239

Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro

Milković, Lidija; Vuković, Tea; Žarković, Neven; Tatzber, F.; Bisenieks, E.; Kalme, Z.; Bruvere, I.; Ogle, Z.; Poikans, J.; Velena, A.; Duburs, G.
Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro // Antioxidants, 7 (2018), 9; 123, 23 doi:10.3390/antiox7090123 (međunarodna recenzija, članak, znanstveni)

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Naslov
Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro

Autori
Milković, Lidija ; Vuković, Tea ; Žarković, Neven ; Tatzber, F. ; Bisenieks, E. ; Kalme, Z. ; Bruvere, I. ; Ogle, Z. ; Poikans, J. ; Velena, A. ; Duburs, G.

Izvornik
Antioxidants (2076-3921) 7 (2018), 9; 123, 23

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1, 4-dihydropyridine(s) (DHPs) ; oxidative stress ; reactive oxygen species (ROS) ; antioxidant (AO) ; antioxidative activity (AOA) ; glutathione ; cell viability and proliferation ; 4-hydroxynonenal (4-HNE)

Sažetak
Oxidative stress has been implicated in pathophysiology of different human stress- and age-associated disorders, including osteoporosis for which antioxidants could be considered as therapeutic remedies as was suggested recently. The 1, 4-dihydropyridine (DHP) derivatives are known for their pleiotropic activity, with some also acting as antioxidants. To find compounds with potential antioxidative activity, a group of 27 structurally diverse DHPs, as well as one pyridine compound, were studied. A group of 11 DHPs with 10-fold higher antioxidative potential than of uricacid, were further tested in cell model of human osteoblast-like cells. Short-term combined effects ofDHPs and 50μM H2O2(1-h each), revealed better antioxidative potential of DHPs if administered before a stressor. Indirect 24-h effect of DHPs was evaluated in cells further exposed to mild oxidative stress conditions induced either by H2O2or tert-butyl hydroperoxide (both 50μM). Cell growth(viability and proliferation), generation of ROS and intracellular glutathione concentration were evaluated. The promotion of cell growth was highly dependent on the concentrations of DHPs used, type of stressor applied and treatment set-up. ThiocarbatoneIII-1, E2-134-1III-4, CarbatoneII-1, AV-153IV-1, and Diethone I could be considered as therapeutic agents for osteoporosis although further research is needed to elucidate their bioactivity mechanisms, in particular in respect to signaling pathways involving 4-hydroxynoneal and related second messengers of free radicals.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Lidija Milković (autor)

Avatar Url Neven Žarković (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com fulir.irb.hr

Citiraj ovu publikaciju:

Milković, Lidija; Vuković, Tea; Žarković, Neven; Tatzber, F.; Bisenieks, E.; Kalme, Z.; Bruvere, I.; Ogle, Z.; Poikans, J.; Velena, A.; Duburs, G.
Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro // Antioxidants, 7 (2018), 9; 123, 23 doi:10.3390/antiox7090123 (međunarodna recenzija, članak, znanstveni)
Milković, L., Vuković, T., Žarković, N., Tatzber, F., Bisenieks, E., Kalme, Z., Bruvere, I., Ogle, Z., Poikans, J., Velena, A. & Duburs, G. (2018) Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro. Antioxidants, 7 (9), 123, 23 doi:10.3390/antiox7090123.
@article{article, author = {Milkovi\'{c}, Lidija and Vukovi\'{c}, Tea and \v{Z}arkovi\'{c}, Neven and Tatzber, F. and Bisenieks, E. and Kalme, Z. and Bruvere, I. and Ogle, Z. and Poikans, J. and Velena, A. and Duburs, G.}, year = {2018}, pages = {23}, DOI = {10.3390/antiox7090123}, chapter = {123}, keywords = {1, 4-dihydropyridine(s) (DHPs), oxidative stress, reactive oxygen species (ROS), antioxidant (AO), antioxidative activity (AOA), glutathione, cell viability and proliferation, 4-hydroxynonenal (4-HNE)}, journal = {Antioxidants}, doi = {10.3390/antiox7090123}, volume = {7}, number = {9}, issn = {2076-3921}, title = {Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro}, keyword = {1, 4-dihydropyridine(s) (DHPs), oxidative stress, reactive oxygen species (ROS), antioxidant (AO), antioxidative activity (AOA), glutathione, cell viability and proliferation, 4-hydroxynonenal (4-HNE)}, chapternumber = {123} }
@article{article, author = {Milkovi\'{c}, Lidija and Vukovi\'{c}, Tea and \v{Z}arkovi\'{c}, Neven and Tatzber, F. and Bisenieks, E. and Kalme, Z. and Bruvere, I. and Ogle, Z. and Poikans, J. and Velena, A. and Duburs, G.}, year = {2018}, pages = {23}, DOI = {10.3390/antiox7090123}, chapter = {123}, keywords = {1, 4-dihydropyridine(s) (DHPs), oxidative stress, reactive oxygen species (ROS), antioxidant (AO), antioxidative activity (AOA), glutathione, cell viability and proliferation, 4-hydroxynonenal (4-HNE)}, journal = {Antioxidants}, doi = {10.3390/antiox7090123}, volume = {7}, number = {9}, issn = {2076-3921}, title = {Antioxidative 1, 4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro}, keyword = {1, 4-dihydropyridine(s) (DHPs), oxidative stress, reactive oxygen species (ROS), antioxidant (AO), antioxidative activity (AOA), glutathione, cell viability and proliferation, 4-hydroxynonenal (4-HNE)}, chapternumber = {123} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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