Naslov
Aortic and Cerebral Aneurysms: Link with Genetic Predisposition, Risk Factors, and Aortopathies

Autori
Švitek, Luka ; Pušeljić, Nora ; Breškić Ćurić, Željka ; Selthofer-Relatić, Kristina

Izvornik
Southeastern European Medical Journal (2459-9484) 3 (2019), 1; 29-41

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
atherosclerosis, aortic aneurysm, genetics, inflammation, intracranial aneurysm

Sažetak
Routine cardiology practice includes diagnostic algorithms for thoracic aortic aneurysm detection at varying degrees of clinical significance. Standard procedures for evaluation and follow up involve screening for standard atherosclerotic risk factors, including hypertension, dyslipidemia, diabetes mellitus, obesity, smoking history and family history without genetic testing, as well as cardiac imaging techniques, such as echocardiography, computedtomography or magnetic resonance imaging. According to the latest reports, thoracic aortic aneurysms can present concomitantly with intracranial aneurysms, although the exact etiopathogenic mechanisms are not yet known. There is evidence that connects these two conditions with genetic predisposition, risk factors, and aortopathies. Routine practice does not include screening for other aneurysm locations. This review will highlight existing knowledge in this area and the need for further investigations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA