Naslov
Global longitudinal strain in patients with severe aortic stenosis and preserved left ventricular systolic function: a single center study using two-dimensional speckle tracking echocardiography
(Global longitudinal strain in patients with severe aortic stenosis and preserved left ventricular systolic function: a single center study using two-dimensional speckle tracking echocardiography)

Autori
Jurin, Ivana ; Šušnjar, Dubravka ; Varvodić, Josip ; Rudež, Igor ; Paić, Frane ; Hadžibegović, Irzal

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Cardiologia croatica, 13 (2018), 5-6 / - , 2018, 199-199

Skup
CroValv 2018 - 4th Congress of the Working Group on Valvular Diseases of the Croatian Cardiac Society with international participation

Mjesto i datum
Zagreb, Hrvatska, 08.06.2018. - 09.06.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
global longitudinal strain, severe aortic stenosis, preserved systolic function.

Sažetak
Background: Strain imaging is an established method for the accurate quantification of left ventricular function and left ventricular global longitudinal strain (GLS) has been shown to be a superior marker of contractility than ejection fraction (EF), and also a good marker for prognosis of patients with aortic stenosis (AS). We prospectively analyzed GLS in context to other relevant clinical parameters in patients with severe aortic stenosis and preserved EF. Patients and Methods: We preoperatively measured GLS in 42 patients with EF > 45% and severe AS. GLS was obtained using 2D speckle tracking echocardiography and patients were divided into four groups according to GLS quartiles. Relevant clinical and echocardiographic parameters were analyzed in relation to GLS, together with curve estimation regression analyses using GLS as independent variable. Results: In all, mean EF was 59.3% (SD 8.4%) and mean aortic valve area (AVA) was 0.74 cm2 (SD 0.17 cm2). Mean GLS was -16.85% (SD -3.58%) with four groups of patients according to quartiles. Group 1 consisted of 12 patients with mean GLS -20.46%, group 2 of 11 patients with mean GLS -18.85%, group 3 of 10 patients with mean GLS -15.43%, and group 4 represented 8 patients with mean GLS -10.67%. Among many clinical and echocardiographic parameters analyzed, groups differed significantly only by eGFR with group 3 having the lowest value (Kruskal Wallis, p=0.034). Curve estimation regression analysis using GLS as independent variable showed only statistically significant negative correlation of GLS with AVA (beta -0.347, R square 0.12, p=0.026). Left atrial volume index (LAVI) showed nearly significant positive correlation with GLS (beta 0.283, R square 0.08, p=0.06) whereas other parameters showed insignificant correlation. Conclusions: Almost one third of patients with preserved EF and severe AS have impaired left ventricular function measured with GLS. AVA and LAVI showed to be good predictors of impaired global ejection fraction. GLS should be used as an additional marker of left ventricular disfunction in all patients with severe aortic stenosis in order to select asymptomatic candidates for early treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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