Naslov
Life‐long tolerance and chimerism in parental mice induced with F1 hybrid cells

Autori
Silobrčić, Vlatko

Izvornik
European journal of immunology (0014-2980) 1 (1971), 5; 313-315

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allotransplantation ; cell division ; cytology ; histocompatibility ; immunological tolerance ; skin transplantation ; animals, newborn ; immune tolerance ; lymph nodes ; mice, inbred strains ; skin transplantation ; transplantation immunology ; transplantation, homologous

Sažetak
We have induced specific immunological tolerance towards (C57BL × CBA‐T6T6) F1 skin grafts in newborn recipients of the parental CBA strain by one injection of 20 × 106 or 40 × 106 F1 spleen cells. Approximately 80 % of the CBA recipients were highly tolerant (the grafts survived for more than 50 days). Many of the highly tolerant mice retained fully preserved grafts until natural death. The highly tolerant CBA mice had dividing (C57BL × CBA‐T6T6) F1 cells in their spleen (12–13 %) and lymph nodes (12–15 %). The proportion of these cells decreased with time, but we found a few of them even at 567 days of life (0.7 and 4.2 %, respectively). We have concluded that specific immunological tolerance to tissue grafts induced at birth can last throughout the entire life‐span of a mouse. The tolerance persists in spite of a very low proportion of dividing donor cells within the lymphoid tissue of tolerant hosts.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je na hrvatskom jeziku pod naslovom "Tolerantnost i kimerizam u miševa roditeljskog soja inducirani stanicama slezene križanaca F1" objavljen i u Radovi Imunološkog zavoda (13) str. 63-78.

POVEZANOST RADA