Naslov
Reduction of GvH splenomegaly in mice by antilymphocyte serum (ALS) : correlation of the effect with immunosuppressive potency of ALS

Autori
Mažuran, Renata ; Volić, B. ; Silobrčić, Vlatko

Izvornik
Zeitschrift für Immunitätsforschung, experimentelle und klinische Immunologie (0300-872X) 147 (1974), 4; 378-383

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
graft survival ; graft versus host reaction ; immunosuppressive treatment ; lymphocyte transfer ; rosette inhibition test ; graft vs host reaction ; immunosuppression ; lymphocyte transfusion ; mice, Inbred C57BL ; skin transplantation ; splenomegaly ; transplantation, homologous

Sažetak
An injection of 107 C57BL lymphocytes into lethally irradiated (950 R) CBA mice produced a reproducible splenomegaly in irradiated recipients. The splenomegaly, caused by proliferation of the injected lymphocytes, reaches its peak 4 days after the injection of cells. The enlargement of the spleen can be partially or totally prevented by rabbit antimouse lymphocyte serum (ALS). The serum was injected intraperitoneally (0.1 ml/mouse) on each of the first 4 days after the injection of lymphocytes. This way, the ability of 5 different ALS to suppress the splenomegaly was evaluated. The potential of a given ALS to inhibit development of spleen enlargement correlated well (r=-0.96, P<0.01) with its capacity to prolong survival of (C57BL X CBA) Fl skin grafts on C57BL recipients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prezentiran na skupu Sixty-Seventh Annual Meeting of the American Association for Cancer Research održanom od 05.-06.05.1976.g., Toronto, Kanada (https://doi.org/10.1093/jnci/56.1.201-c);
objavljen kao sažetak u Journal of the National Cancer Institute 56 (1976) 1, str. 17.

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