Naslov
A comparison of the antitumor effect of Corynebacterium parvum and glucan in mice

Autori
Silobrčić, Vlatko ; Elman, Arthur ; Suit, Herman D. ; Steele, Edvin L.

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Immune modulation and control of neoplasia by adjuvant therapy

Urednik/ci
Chirigos, Michael A.

Izdavač
Raven Press

Grad
New York (NY)

Godina
1978

Raspon stranica
235-240

ISBN
978-0890042205

Ključne riječi
Corynebacterium parvum vaccine ; glucan ; dose response ; drug comparison ; drug efficacydrug response ; drug screening ; intravenous drug administration ; squamous cell carcinoma

Sažetak
Glucan is a simple polyglucose molecule, minimally toxic and readily synthesized, that stimulates the RES system and has anantitumor effect. C parvum is a known stimulator of the RES syste mwith a pronounced antitumoreffect, and anappreciable toxicity. In this study, wecompared the efficacy of glucan to induce regression of 5 mm fibrosarcoma growing as isotransplants in the mouse leg to the well-documented antitumor effect of C parvum in the same animal tumor model system. An I.V. injection of 350 meg of C parvum causes complete and permanent regression of 30-50 % of such tumors. Glucan was administered in travenously in doses of 200, 350, and 1000 meg. on day 5, or as three injections of the same dose on days 5, 10, and 15 following tumor transplantation. Single doses of 200 and 350 meg. cured n omice, but a single injection of 1000 meg. of glucan cured 3 of 15 mice, and of 15 tumor hosts were cured by 3 x 1000 meg. No instance of enhancement of tumor growth was observed. Therefore, in this system, glucan, when applied in 1000 meg. doses, can be as effective as C parvum. Current studies include (1) increasing doses of glucan, and (2) effective ness of combining glucan with local radiation the rapy in a highly radiation resistant squamous cell carcinoma. This investigation was supported in part by Grant Number 2 ROI CA133ll, awarded by the National Cancer Institute, DHEW.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prezentiran na skupu 1976 ASTR, održanom 1978.g. ; kao sažetak objavljen u časopisu International journal of radiation oncology, biology, physics (1976) (S1), str. 80.

POVEZANOST RADA