Naslov
Local control and disease-free survival after treatment of a squamous cell carcinoma by Corynebacterium parvum and local irradiation

Autori
Suit, Herman D. ; Sedlaček, Robert ; Silobrčić, Vlatko

Izvornik
Cancer research (Baltimore) (0008-5472) 37 (1977), 11; 3869-3875

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer graft ; cancer growth ; cancer immunotherapy ; cancer transplantation ; corynebacterium parvum ; drug therapy ; gamma radiationin ; travenous drug administration ; leg tumor ; squamous cell carcinoma ; dose-response relationship, radiation ; Mice, Inbred C3H ; neoplasm metastasis ; neoplasm transplantation ; neoplasms, experimental ; propionibacterium acnes ; remission, spontaneous ; immunotherapy ; transplantation, isogeneic
(cancer graft ; cancer growth ; cancer immunotherapy ; cancer transplantation ; corynebacterium parvum ; drug therapy ; gamma radiationin ; travenous drug administration ; leg tumor ; squamous cell carcinoma ; dose-response relationship, radiation ; Mice, Inbred C3H ; neoplasm metastasis ; neoplasm transplantation ; neoplasms, experimental ; propionibacterium acnes ; remission, spontaneous ; transplantation, isogeneic)

Sažetak
Studies have been completed on the efficacy of combining Corynebacterium parvum with local irradiation of a highly-radiation-resistant and actively metastasizing squamous cell carcinoma. The tumor was studied as isotransplants growing in the mouse leg. C. parvum was given alone or in combination with local irradiation or amputation. C. parvum given intralesionally and i.v. in 350-µg doses retarded growth of 3- or 5-mm tumors. Complete and permanent regression of one 3-mm tumor was achieved by C. parvum alone. Radiation was administered at tumor diameters of 5, 8, or 12 mm ; this was ≃2 to 3 days after the start of the C. parvum injections. C. parvum treatments reduced significantly the dose required for inactivation of tumor of the 5- and 8-mm but not the 12-mm tumor. The radiation dose, that would on the average be expected to result in control of one-half of the irradiated tumors for control and C. parvum-treated mice were, respectively, 6320 and 3060 rads for 5-mm tumors and 7340 and 6160 rads for 8-mm tumors. An important benefit of C. parvum treatment in animals with 8-mm tumors was a reduction in the frequency of death due to metastatic disease from 55% to 24% among mice in which the leg tumor had been successfully irradiated. Metastases were rare in mice treated when the tumor size was 5 mm, but they developed in nearly every mouse treated for a 12-mm tumor (control and C. parvum groups). C. parvum caused comparable improvements in survival when combined with radiation or with amputation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prezentiran na skupu 67th Annual Meeting of The American Association fot Cancer Research, održanom u svubnju 1976.g., Toronto, Kanada.

POVEZANOST RADA