Naslov
Vascular effects of low dosed chlortalidone in mild hypertensives

Autori
Bagatin, Jugoslav ; Pavličević, Ivančica ; Sardelić, Sanda ; Rumboldt, Zvonko.

Izvornik
International journal of clinical pharmacology research (0251-1649) 15 (1995), 5-6; 201-208

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chlortalidone, hypertension, low dosage, antihypertensive, treatment

Sažetak
INTRODUCTION: Two low doses of chlortalidone (12.5 and 25 mg per day) have been compared in a cross-over, double-blind study in 30 mild to moderate hypertensives of either gender, most of whom had developed the problem recently. RESULTS: The antihypertensive effects of both doses were comparable, with an approximately 8% reduction in mean arterial pressure ; also, plethismographic parameters such as peak flow, venous capacity and venous outflow increased significantly with both doses. CONCLUSION: The 12.5 mg dose of chlortalidone appear to be as effective as an antihypertensive agent as the 25 mg dose, with possibly much less adverse effects.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA