Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Gudelj, Ivan; Salo, Perttu P.; Trbojević- Akmačić, Irena; Albers, Malena; Primorac, Dragan; Perola, Markus; Lauc, Gordan

doi:10.1016/j.bbadis.2018.03.018

Pregled bibliografske jedinice broj: 1002551

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Gudelj, Ivan; Salo, Perttu P.; Trbojević- Akmačić, Irena; Albers, Malena; Primorac, Dragan; Perola, Markus; Lauc, Gordan

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up // Biochimica et biophysica acta-molecular basis of disease, 1864 (2018), 6, A; 2034-2039 doi:10.1016/j.bbadis.2018.03.018 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1002551 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Autori
Gudelj, Ivan ; Salo, Perttu P. ; Trbojević- Akmačić, Irena ; Albers, Malena ; Primorac, Dragan ; Perola, Markus ; Lauc, Gordan

Izvornik
Biochimica et biophysica acta-molecular basis of disease (0925-4439) 1864 (2018), 6, A; 2034-2039

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biomarker ; immunoglobulin G ; N-glycans ; rheumatoid arthritis ; risk factor

Sažetak
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one of the most prevalent chronic inflammatory diseases which primarily involves the joints. Most RA patients develop autoantibodies against immunoglobulin G (IgG) and changes in IgG glycosylation have been associated with RA. We undertook this study to determine whether altered IgG glycosylation precedes the disease diagnosis. We studied IgG glycosylation in RA in two prospective cohorts (N = 14, 749) by measuring 28 IgG glycan traits in 179 subjects who developed RA within 10- years follow-up and 358 matched controls. Ultra-performance liquid chromatography method based on hydrophilic interactions (HILIC- UPLC) was used to analyse IgG glycans. Future RA diagnosis associated with traits related to lower galactosylation and sialylation of IgG when comparing the cases to the matched controls. In RA cases, these traits did not correlate with the time between being recruited to the study and being diagnosed with RA (median time 4.31 years). The difference in IgG glycosylation was relatively stable and present years before diagnosis. This indicates that long-acting factors affecting IgG glycome composition are among the underlying mechanisms of RA and that decreased galactosylation is a pre-existing risk factor involved in the disease development.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Rijeka,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
Dječja bolnica Srebrnjak,
GENOS d.o.o.,
Specijalna bolnica Sv. Katarina

Profili:

Gordan Lauc (autor)