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Pregled bibliografske jedinice broj: 1001916

In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms

Bedenić, Branka; Car, Haris; Slačanac, Domagoj; Sviben, Mario; Čačić, Marko; Lukić-Grlić, Amarela; Benčić, Ana; Šijak, Dorotea; Tripković, Marko; Beader, Nataša
In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms // JOURNAL OF INFECTION AND CHEMOTHERAPY, 24 (2018), 12; 1016-1019 doi:10.1016/j.jiac.2018.06.001 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1001916 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms
(In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms)

Autori
Bedenić, Branka ; Car, Haris ; Slačanac, Domagoj ; Sviben, Mario ; Čačić, Marko ; Lukić-Grlić, Amarela ; Benčić, Ana ; Šijak, Dorotea ; Tripković, Marko ; Beader, Nataša

Izvornik
JOURNAL OF INFECTION AND CHEMOTHERAPY (1341-321X) 24 (2018), 12; 1016-1019

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
carbapenem resistance ; Klebsiella pneumoniae ; colistin, ; VIM-1 ; NDM ; -1 OXA-48

Sažetak
Aim: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases ; combinations of two metallo-β-lactamases (MBL) or MBL with OXA-48. Colistin-resistant strain positive for OXA-48 was also included in the study. Methods: The antibiotic susceptibility was tested by broth microdilution method. Synergy was tested by chequerboard, time-kill and 2- well method. PAE was determined by viable counting. Results:The chequerboard analysis revealed synergy for colistin combination with meropenem in all isolates with FICI values ranging from 0.12 to 0.24. FICI values for combinations with vancomycin were below 0.5 indicating synergy in two out of four isolates. K. pneumoniae 609815 positive for OXA-48 and colistin resistant showed the most pronounced and consistent synergy effect with meropenem in both chequerboard and time-kill method. Synergy effect in time-kill curves, was observed for K pneumoniae 145846 with two MBLs and colistin resistant K. pneumoniae 609815 positive for OXA-48, with both combinations including meropenem and vancomycin. Colistin alone exhibited short postantibiotic effect (PAE) against all tested isolates. Meropenem markedly prolonged the PAE in two isolates in contrast to vancomycin which did not demonstrate significant effect on the duration of PAE Conclusions: The synergy effect and the duration of PAE was strain and antibiotic dependent but not related to the resistance gene content.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-108-1080114-0015 - Mehanizmi rezistencije na antibiotike u Gram-negativnih bakterija (Bedenić, Branka, MZOS ) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Klinika za dječje bolesti

Profili:

Avatar Url Amarela Lukić-Grlić (autor)

Avatar Url Mario Sviben (autor)

Avatar Url Nataša Beader (autor)

Avatar Url Branka Bedenić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Bedenić, Branka; Car, Haris; Slačanac, Domagoj; Sviben, Mario; Čačić, Marko; Lukić-Grlić, Amarela; Benčić, Ana; Šijak, Dorotea; Tripković, Marko; Beader, Nataša
In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms // JOURNAL OF INFECTION AND CHEMOTHERAPY, 24 (2018), 12; 1016-1019 doi:10.1016/j.jiac.2018.06.001 (međunarodna recenzija, članak, znanstveni)
Bedenić, B., Car, H., Slačanac, D., Sviben, M., Čačić, M., Lukić-Grlić, A., Benčić, A., Šijak, D., Tripković, M. & Beader, N. (2018) In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms. JOURNAL OF INFECTION AND CHEMOTHERAPY, 24 (12), 1016-1019 doi:10.1016/j.jiac.2018.06.001.
@article{article, author = {Bedeni\'{c}, Branka and Car, Haris and Sla\v{c}anac, Domagoj and Sviben, Mario and \v{C}a\v{c}i\'{c}, Marko and Luki\'{c}-Grli\'{c}, Amarela and Ben\v{c}i\'{c}, Ana and \v{S}ijak, Dorotea and Tripkovi\'{c}, Marko and Beader, Nata\v{s}a}, year = {2018}, pages = {1016-1019}, DOI = {10.1016/j.jiac.2018.06.001}, keywords = {carbapenem resistance, Klebsiella pneumoniae, colistin,, VIM-1, NDM, -1 OXA-48}, journal = {JOURNAL OF INFECTION AND CHEMOTHERAPY}, doi = {10.1016/j.jiac.2018.06.001}, volume = {24}, number = {12}, issn = {1341-321X}, title = {In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms}, keyword = {carbapenem resistance, Klebsiella pneumoniae, colistin,, VIM-1, NDM, -1 OXA-48} }
@article{article, author = {Bedeni\'{c}, Branka and Car, Haris and Sla\v{c}anac, Domagoj and Sviben, Mario and \v{C}a\v{c}i\'{c}, Marko and Luki\'{c}-Grli\'{c}, Amarela and Ben\v{c}i\'{c}, Ana and \v{S}ijak, Dorotea and Tripkovi\'{c}, Marko and Beader, Nata\v{s}a}, year = {2018}, pages = {1016-1019}, DOI = {10.1016/j.jiac.2018.06.001}, keywords = {carbapenem resistance, Klebsiella pneumoniae, colistin,, VIM-1, NDM, -1 OXA-48}, journal = {JOURNAL OF INFECTION AND CHEMOTHERAPY}, doi = {10.1016/j.jiac.2018.06.001}, volume = {24}, number = {12}, issn = {1341-321X}, title = {In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against enterobacteriaceae with multiple carbapenem resistance mechanisms}, keyword = {carbapenem resistance, Klebsiella pneumoniae, colistin,, VIM-1, NDM, -1 OXA-48} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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