Naslov
Protutumorska aktivnost novih benzimidazolnih amidinskih derivata 7‐klor‐4‐ aminokinolina
(Antitumor activity of novel benzimidazole amidine derivatives of 7‐chloro‐4‐ aminoquinoline)

Autori
Luka KRSTULOVIĆ, Marijana Jukić, Teuta Opačak‐Bernardi, Kristina Starčević, Miroslav Bajić, Ljubica Glavaš‐Obrovac

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
26. hrvatski skup kemičara i kemijskih inženjera, Šibenik, 2019. / Galić, Nives ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019, 114-114

ISBN
9789536894673

Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog

Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
hibridne molekule, 7-klor-4-aminokinolin, benzimidazolni amidini, protumorsko djelovanje
(hybrid molecules, 7‐chloro‐4‐aminoquinoline, benzimidazole amidines, anticancer activity)

Sažetak
As a part of our ongoing effort to prepare novel biologically active compounds, we have synthesized a short series of hybrid molecules in which 7‐chloro‐4‐aminoquinoline is linked to benzimidazole amidine moiety via m‐phenyl linker [1]. Several 7‐chloro‐4‐aminoquinoline based antimalarial therapeutics are tested for their anticancer activity, two of them (chloroquine and hydroxychloroquine) are currently investigated in clinical trials for cancer therapy [2]. Benzimidazole moiety is found in many known pharmaceuticals displaying, besides anticancer, a variety of biological effects [3]. Positively charged amidine groups are known for their cellular and nuclear uptake. Novel compounds were evaluated for their in vitro cytotoxic activity against normal epithelial (MDCK1) and carcinoma (HeLa, CaCo2, SW‐620, MCF‐7 and MDAMB231) cell lines using MTT assay.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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