Naslov
Cancer cell growth inhibition by aroylhydrazone derivatives

Autori
Iliev, Ivan ; Kontrec, Darko ; Detcheva, Roumiana ; Georgieva, Maya ; Balacheva, Anelia ; Galić, Nives ; Pajpanova, Tamara

Izvornik
Biotechnology & biotechnological equipment (1310-2818) 33 (2019), 1; 756-763

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aroylhydrazones ; nicotinic acid hydrazide ; isonicotinic acid hydrazide ; antiproliferative activity

Sažetak
Hydrazones have versatile properties that make them promising for a range of possible applications. In this study, we examined a library of 17 aroylhydrazones derived from nicotinic acid hydrazide (1-12) and isonicotinic acid hydrazide (A-E) created by us for their biological activity. The antiproliferative activity of the compounds was investigated on non-tumour MCF-10A cells and cancer cell lines, MCF-7 and MDA-MB-231. Four compounds were selected as most active in cell growth inhibition of the tumour cell lines. These compounds, 5, 11, C and E, were tested on four additional cell lines: nontumour BJ and cancer cell lines, HeLa, HepG2 and HT-29. Compounds 5 and E exhibited the highest selectivity index on cancer cell lines MDA-MB-231, HeLa and HepG2. High selectivity to MCF-7 cells was demonstrated with compound 5. Compound C was very selective to HepG2 cells as well as to MDA-MB-231 but to a lesser degree. Compound 11 showed selectivity against MDA-MB- 231. The obtained results allow assessing the structure–activity relationship of the compounds and provide insight into the further development of this group of aroylhydrazones as more potent and selective anti-neoplastic agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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