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Pregled bibliografske jedinice broj: 996890

Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes

Zorbaz, Tamara; Malinak, David; Kuca, Kamil; Musilek, Kamil; Kovarik, Zrinka
Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes // Chemico-Biological Interactions, 307 (2019), 16-20 doi:10.1016/j.cbi.2019.04.020 (međunarodna recenzija, članak, znanstveni)

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Naslov
Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes

Autori
Zorbaz, Tamara ; Malinak, David ; Kuca, Kamil ; Musilek, Kamil ; Kovarik, Zrinka

Izvornik
Chemico-Biological Interactions (0009-2797) 307 (2019); 16-20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
organophosphorus compounds ; quaternary oxime ; reactivators ; cholinesterase ; pseudo-catalytic scavenger

Sažetak
Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho- positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents, were tested in the reactivation of human butyrylcholinesterase (BChE) inhibited by sarin, cyclosarin, VX, and tabun. A previously highlighted AChE reactivator, dichlorinated bispyridinium oxime with propyl linker (K868), was tested in more detail for reactivation of four nerve agent-BChE conjugates. Its BChE reactivation potency was showed to be promising when compared to the standard oximes used in medical practice, asoxime (HI-6) and pralidoxime (2-PAM), especially in case of sarin and tabun. This finding could be used in the pseudo-catalytic scavenging of the most nerve agents due to its cumulative capacity to reactivate both AChE and BChE.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija



POVEZANOST RADA

Projekti:
HRZZ-IP-2018-01-7683 - Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima (AnalyseBChE) (Kovarik, Zrinka, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Tamara Zorbaz (autor)

Avatar Url Zrinka Kovarik (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.sciencedirect.com

Citiraj ovu publikaciju:

Zorbaz, Tamara; Malinak, David; Kuca, Kamil; Musilek, Kamil; Kovarik, Zrinka
Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes // Chemico-Biological Interactions, 307 (2019), 16-20 doi:10.1016/j.cbi.2019.04.020 (međunarodna recenzija, članak, znanstveni)
Zorbaz, T., Malinak, D., Kuca, K., Musilek, K. & Kovarik, Z. (2019) Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes. Chemico-Biological Interactions, 307, 16-20 doi:10.1016/j.cbi.2019.04.020.
@article{article, author = {Zorbaz, Tamara and Malinak, David and Kuca, Kamil and Musilek, Kamil and Kovarik, Zrinka}, year = {2019}, pages = {16-20}, DOI = {10.1016/j.cbi.2019.04.020}, keywords = {organophosphorus compounds, quaternary oxime, reactivators, cholinesterase, pseudo-catalytic scavenger}, journal = {Chemico-Biological Interactions}, doi = {10.1016/j.cbi.2019.04.020}, volume = {307}, issn = {0009-2797}, title = {Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes}, keyword = {organophosphorus compounds, quaternary oxime, reactivators, cholinesterase, pseudo-catalytic scavenger} }
@article{article, author = {Zorbaz, Tamara and Malinak, David and Kuca, Kamil and Musilek, Kamil and Kovarik, Zrinka}, year = {2019}, pages = {16-20}, DOI = {10.1016/j.cbi.2019.04.020}, keywords = {organophosphorus compounds, quaternary oxime, reactivators, cholinesterase, pseudo-catalytic scavenger}, journal = {Chemico-Biological Interactions}, doi = {10.1016/j.cbi.2019.04.020}, volume = {307}, issn = {0009-2797}, title = {Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes}, keyword = {organophosphorus compounds, quaternary oxime, reactivators, cholinesterase, pseudo-catalytic scavenger} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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