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Pregled bibliografske jedinice broj: 996188

Synthesis and antiproliferative activity of adamantyl kojic acid derivatives


Petrović Peroković, Vesna; Car, Željka; Usenik, Andrea; Opačak-Bernardi, Teuta; Jurić, Andrea; Tomić, Srđanka
Synthesis and antiproliferative activity of adamantyl kojic acid derivatives // 26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Galić, Nives ; Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 151-151 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 996188 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and antiproliferative activity of adamantyl kojic acid derivatives

Autori
Petrović Peroković, Vesna ; Car, Željka ; Usenik, Andrea ; Opačak-Bernardi, Teuta ; Jurić, Andrea ; Tomić, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Galić, Nives ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019, 151-151

ISBN
978-953-6894-67-3

Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog

Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Kojic acid ; Maltol ; Adamantyl ; Antiproliferation ; Cancer

Sažetak
Kojic acid is a chelating compound and a common fungal metabolite widely used primarily in the preparation of cosmetic biomaterials and skin care products [1]. Numerous studies also showed that kojic acid and its derivatives exhibit other various biological activities [2, 3]. In view of our previous findings on the adamantyl pyridinone derivatives and our continuous investigation of their biological activity [4] we wanted to extend our research further and explore the influence of the adamantyl group on the biological activity of pyranone system as well. Thus, esters of kojic and adamantan‐1‐ylacetic acid were prepared using efficient synthetic methods in good yields and evaluated for their in vitro antiproliferative activity on 4 cancer cell lines (K562, HeLa, Caco‐ 2, NCI‐H358) as well as on normal cells (MDCK). Compounds showed good to moderate in vitro antiproliferative acitvity with IC50 values ranging from 13.1 to 43.0 μM. It seems that the presence and adequate position of the adamantyl acyl group or chlorine atom is a prerequisite for their antitumor activity. The presence and the position of the adamantyl acyl unit were also the important structural parameters that governed antiproliferative activity of our previously investigated pyridin‐4‐ one derivatives.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-7899 - Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikonjugata (PEPTGLYCOSAR) (Tomić-Pisarović, Srđanka, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Osijek,
Sveučilište u Osijeku - Odjel za kemiju

Poveznice na cjeloviti tekst rada:

www.hdki.hr

Citiraj ovu publikaciju:

Petrović Peroković, Vesna; Car, Željka; Usenik, Andrea; Opačak-Bernardi, Teuta; Jurić, Andrea; Tomić, Srđanka
Synthesis and antiproliferative activity of adamantyl kojic acid derivatives // 26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Galić, Nives ; Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 151-151 (poster, domaća recenzija, sažetak, znanstveni)
Petrović Peroković, V., Car, Ž., Usenik, A., Opačak-Bernardi, T., Jurić, A. & Tomić, S. (2019) Synthesis and antiproliferative activity of adamantyl kojic acid derivatives. U: Galić, N. & Rogošić, M. (ur.)26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka.
@article{article, author = {Petrovi\'{c} Perokovi\'{c}, Vesna and Car, \v{Z}eljka and Usenik, Andrea and Opa\v{c}ak-Bernardi, Teuta and Juri\'{c}, Andrea and Tomi\'{c}, Sr\djanka}, year = {2019}, pages = {151-151}, keywords = {Kojic acid, Maltol, Adamantyl, Antiproliferation, Cancer}, isbn = {978-953-6894-67-3}, title = {Synthesis and antiproliferative activity of adamantyl kojic acid derivatives}, keyword = {Kojic acid, Maltol, Adamantyl, Antiproliferation, Cancer}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {\v{S}ibenik, Hrvatska} }
@article{article, author = {Petrovi\'{c} Perokovi\'{c}, Vesna and Car, \v{Z}eljka and Usenik, Andrea and Opa\v{c}ak-Bernardi, Teuta and Juri\'{c}, Andrea and Tomi\'{c}, Sr\djanka}, year = {2019}, pages = {151-151}, keywords = {Kojic acid, Maltol, Adamantyl, Antiproliferation, Cancer}, isbn = {978-953-6894-67-3}, title = {Synthesis and antiproliferative activity of adamantyl kojic acid derivatives}, keyword = {Kojic acid, Maltol, Adamantyl, Antiproliferation, Cancer}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {\v{S}ibenik, Hrvatska} }




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