Pregled bibliografske jedinice broj: 996188
Synthesis and antiproliferative activity of adamantyl kojic acid derivatives
Synthesis and antiproliferative activity of adamantyl kojic acid derivatives // 26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Galić, Nives ; Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 151-151 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 996188 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and antiproliferative activity of
adamantyl kojic acid derivatives
Autori
Petrović Peroković, Vesna ; Car, Željka ; Usenik, Andrea ; Opačak-Bernardi, Teuta ; Jurić, Andrea ; Tomić, Srđanka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka
/ Galić, Nives ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019, 151-151
ISBN
978-953-6894-67-3
Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog
Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
Kojic acid ; Maltol ; Adamantyl ; Antiproliferation ; Cancer
Sažetak
Kojic acid is a chelating compound and a common fungal metabolite widely used primarily in the preparation of cosmetic biomaterials and skin care products [1]. Numerous studies also showed that kojic acid and its derivatives exhibit other various biological activities [2, 3]. In view of our previous findings on the adamantyl pyridinone derivatives and our continuous investigation of their biological activity [4] we wanted to extend our research further and explore the influence of the adamantyl group on the biological activity of pyranone system as well. Thus, esters of kojic and adamantan‐1‐ylacetic acid were prepared using efficient synthetic methods in good yields and evaluated for their in vitro antiproliferative activity on 4 cancer cell lines (K562, HeLa, Caco‐ 2, NCI‐H358) as well as on normal cells (MDCK). Compounds showed good to moderate in vitro antiproliferative acitvity with IC50 values ranging from 13.1 to 43.0 μM. It seems that the presence and adequate position of the adamantyl acyl group or chlorine atom is a prerequisite for their antitumor activity. The presence and the position of the adamantyl acyl unit were also the important structural parameters that governed antiproliferative activity of our previously investigated pyridin‐4‐ one derivatives.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-7899 - Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikonjugata (PEPTGLYCOSAR) (Tomić-Pisarović, Srđanka, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Osijek,
Sveučilište u Osijeku - Odjel za kemiju
Profili:
Andrea Dandić
(autor)
Vesna Petrović-Peroković
(autor)
Andrea Usenik
(autor)
Srđanka Tomić-Pisarović
(autor)
Teuta Opačak-Bernardi
(autor)
Željka Car
(autor)