Naslov
Synthesis and antimicrobial potential of bisquaternary ammonium compounds based on quinuclidine-3-ol

Autori
Bazina, Linda ; Soldo, Barbara ; Maravić, Ana ; Primožić, Ines ; Šprung, Matilda ; Odžak, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
26. Hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka / Galić, Nives ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019, 111-111

ISBN
978-953-6894-67-3

Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog

Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Quaternary ammonium compounds (QAC) ; BisQACs ; Antimicrobial activity ; Cytotoxicity

Sažetak
Quaternary ammonium compounds (QACs), as cationic amphiphiles, show broad-spectrum antibacterial activity due to a mechanism based on membrane disruption. Since previously synthesized monoQACs containing quinuclidine-3- ol showed promising antimicrobial potential, we have further developed a new series of bisQACs containing quinuclidine-3-ol. In this series, we bind two quinuclidine centers by long alkyl chains of variable length (C8, C10 and C12), assuming that two-headed (bicephalic) QACs would possess even better ability of bacterial membrane disruption. These compounds were screened for antimicrobial activity against Gram-positive and Gram- negative bacterial strains, both ATCC and clinical isolates, as well as fungi and molds. Activity toward inhibition of the biofilm structures and cytotoxicity were also tested.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA