Naslov
Antiproliferativna aktivnost amidino supstituiranih benzimidazola i benzotiazola ispitana na 2D i 3D staničnim linijama
(Antiproliferative activity of amidino substituted benzimidazoles and benzothiazoles explored by 2D and 3D cell culture system)

Autori
Cindrić, Maja ; Racane, Livio ; Perin, Nataša ; Boček, Ida ; Beč, Anja ; Zlatar, Ivo ; Brajša, Karmen ; Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
26. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka / Galić, Nives ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019, 116-116

ISBN
9789536894673

Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog

Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
amidini, benzimidazoli, benzotiazolii, antiproliferativna aktivnost
(amidines, benzimidazoles, benzothiazoles, antiproliferative activity)

Sažetak
It is well known that amidines are structural parts of numerous compounds of biological interest including important medical and biochemical agents. Amidine substituents placed at the termini of the molecule have great importance in the molecule - biological target interactions allowing the formation of the stable complex with biologically molecules. In our previous studies we have proved that by engrafting amidine extremities as positively charged substituents at the end of the heteroaromatic substructures we could significantly improve the biological activity and orient the function of the molecule toward the binding to an electronegatively charged biological molecule such as DNA [1]. This work presents the synthesis of amidino substituted benzimidazoles and benzothiazoles as a potential biologically active agents. For the synthesis of novel targeted compounds classical organic synthesis reactions were used. Antitumor activity in 2D and 3D cancer cell culture assays on three human lung cancer cell lines (A549, HCC827, NCI-H358) was tested. Doxorubicin, staurosporine and vandetanib were used as control compounds [2].

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA