Pregled bibliografske jedinice broj: 991946
MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth
MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth // Biomaterials, 98 (2016), 192-202 doi:10.1016/j.biomaterials.2016.04.039 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 991946 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth
Autori
Kalafatovic, Daniela ; Nobis, Max ; Son, Jiye ; Anderson, Kurt I. ; Ulijn, Rein V.
Izvornik
Biomaterials (0142-9612) 98
(2016);
192-202
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Peptides ; Self-assembly ; MMP ; Cancer therapy ; Morphology transition
Sažetak
A central challenge in cancer care is to ensure that therapeutic compounds reach their targets. One approach is to use enzyme-responsive biomaterials, which reconfigure in response to endogenous enzymes that are overexpressed in diseased tissues, as potential site-specific anti-tumoral therapies. Here we report peptide micelles that upon MMP-9 catalyzed hydrolysis reconfigure to form fibrillar nanostructures. These structures slowly release a doxorubicin payload at the site of action. Using both in vitro and in vivo models, we demonstrate that the fibrillar depots are formed at the sites of MMP-9 overexpression giving rise to enhanced efficacy of doxorubicin, resulting in inhibition of tumor growth in an animal model.
Izvorni jezik
Engleski
Znanstvena područja
Interdisciplinarne prirodne znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
