Pregled bibliografske jedinice broj: 990916
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer // International journal of molecular sciences, 20 (2019), 5; 1180, 24 doi:10.3390/ijms20051180 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 990916 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
Autori
Novak Kujundžić, Renata ; Stepanić, Višnja ; Milković, Lidija ; Čipak Gašparović, Ana ; Tomljanović, Marko ; Gall-Trošelj, Koraljka
Izvornik
International journal of molecular sciences (1422-0067) 20
(2019), 5;
1180, 24
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
curcumin ; oxidative metabolites ; inflamm-aging ; cancer ; metabolic reprogramming ; direct protein binding ; IL-17 ; STAT3 ; SHMT2
Sažetak
Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti- inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century.
Izvorni jezik
Engleski
Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-4404 - NRF2 na raskrižju epigenetičkog modeliranja, metabolizma i proliferacije stanice raka (CrossEMPATICNRF2) (Gall-Trošelj, Koraljka, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Marko Tomljanović
(autor)
Koraljka Gall Trošelj
(autor)
Ana Čipak Gašparović
(autor)
Lidija Milković
(autor)
Renata Novak Kujundžić
(autor)
Višnja Stepanić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE