Naslov
Molecular basis for different ability of low-density and high-density lipoproteins to support activity of the intrinsic Xase complex

Autori
Khrenov, Alexey ; Sarafanov, Andrey ; Ananyeva, Natalya ; Kouiavskaia, Diana ; Shima, Midori ; Schwinn, Horst ; Josic, Djuro ; Saenko, Evgueni

Izvornik
Thrombosis Research (0049-3848) 105 (2002), 1; 87-93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Factor VIII ; Biosensor chips ; Phospholipid surface ; Plasmon resonance ; Lipoproteins ; Atherosclerosis

Sažetak
Factor VIII (fVIII) is an essential component of the intrinsic pathway of blood coagulation. In this pathway, thrombin-activated fVIII (fVIIIa) functions as a cofactor for a serine protease factor IXa (fIXa), and their complex (Xase complex)activates factor X (fX) to factor Xa (fXa). In its turn, fXa participates in activation of prothrombin into thrombin, the key enzyme of the coagulation cascade. The role of fVIIIa is to increase the catalytic rate constant of conversion of fX into fXa by several orders of magnitude. As the vast majority of catalytic complexes of the coagulation cascade, the Xase complex is assembled and functions on a phospholipid surface. Until recently, cell membranes, particularly those of activated platelets, were considered the only source of phospholipid surface in physiological conditions.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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