Pregled bibliografske jedinice broj: 990290
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives // Molecules, 24 (2019), 6; 1001, 13 doi:10.3390/molecules24061001 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 990290 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
An improved method for the quaternization of
nicotinamide and antifungal activities of its
derivatives
Autori
Siber, Tamara ; Bušić, Valentina ; Zobundžija, Dora ; Roca, Sunčica ; Vikić-Topić, Dražen ; Vrandečić, Karolina ; Gašo-Sokač, Dajana
Izvornik
Molecules (1420-3049) 24
(2019), 6;
1001, 13
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
quaternization ; nicotinamide ; substituted 2-bromoacetophenones ; microwave synthesis ; antifungal activity
Sažetak
The quaternization reactions of nicotinamide, with different electrophiles: methyl iodide and substituted 2-bromoacetophenones (4-Cl, 4-Br, 4-H, 4-CH3, 4-F, 4-OCH3, 4-Ph, 2-OCH3, 4-NO2) are reported. The preparations were carried out by conventional synthesis and under microwave irradiation in absolute ethanol and acetone. The synthesis performed by microwave dielectric heating significantly improved yield, up to 8 times, and shortened down the reaction time from ca. one day in conventional, to 10–20 min. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR spectroscopy, mass spectrometry and elemental analysis. The compounds have been screened for antifungal activities against Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum at concentrations of 10 µg/mL and 100 µg/mL. Six compounds showed the strong inhibition of mycelium growth at a concentration of 10 µg/mL. All tested compounds revealed the great inhibitory activities against S. sclerotiorum at a concentration of 100 µg/mL.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Ustanove:
Fakultet agrobiotehničkih znanosti Osijek,
Institut "Ruđer Bošković", Zagreb,
Prehrambeno-tehnološki fakultet, Osijek,
Sveučilište Jurja Dobrile u Puli
Profili:
Valentina Bušić (autor)
Tamara Siber (autor)
Dajana Gašo-Sokač (autor)
Sunčica Roca (autor)
Dražen Vikić-Topić (autor)
Karolina Vrandečić (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE