Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 990290

An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives


Siber, Tamara; Bušić, Valentina; Zobundžija, Dora; Roca, Sunčica; Vikić-Topić, Dražen; Vrandečić, Karolina; Gašo-Sokač, Dajana
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives // Molecules, 24 (2019), 6; 1001, 13 doi:10.3390/molecules24061001 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 990290 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives

Autori
Siber, Tamara ; Bušić, Valentina ; Zobundžija, Dora ; Roca, Sunčica ; Vikić-Topić, Dražen ; Vrandečić, Karolina ; Gašo-Sokač, Dajana

Izvornik
Molecules (1420-3049) 24 (2019), 6; 1001, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
quaternization ; nicotinamide ; substituted 2-bromoacetophenones ; microwave synthesis ; antifungal activity

Sažetak
The quaternization reactions of nicotinamide, with different electrophiles: methyl iodide and substituted 2-bromoacetophenones (4-Cl, 4-Br, 4-H, 4-CH3, 4-F, 4-OCH3, 4-Ph, 2-OCH3, 4-NO2) are reported. The preparations were carried out by conventional synthesis and under microwave irradiation in absolute ethanol and acetone. The synthesis performed by microwave dielectric heating significantly improved yield, up to 8 times, and shortened down the reaction time from ca. one day in conventional, to 10–20 min. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR spectroscopy, mass spectrometry and elemental analysis. The compounds have been screened for antifungal activities against Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum at concentrations of 10 µg/mL and 100 µg/mL. Six compounds showed the strong inhibition of mycelium growth at a concentration of 10 µg/mL. All tested compounds revealed the great inhibitory activities against S. sclerotiorum at a concentration of 100 µg/mL.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove:
Fakultet agrobiotehničkih znanosti Osijek,
Institut "Ruđer Bošković", Zagreb,
Prehrambeno-tehnološki fakultet, Osijek,
Sveučilište Jurja Dobrile u Puli

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com fulir.irb.hr

Citiraj ovu publikaciju:

Siber, Tamara; Bušić, Valentina; Zobundžija, Dora; Roca, Sunčica; Vikić-Topić, Dražen; Vrandečić, Karolina; Gašo-Sokač, Dajana
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives // Molecules, 24 (2019), 6; 1001, 13 doi:10.3390/molecules24061001 (međunarodna recenzija, članak, znanstveni)
Siber, T., Bušić, V., Zobundžija, D., Roca, S., Vikić-Topić, D., Vrandečić, K. & Gašo-Sokač, D. (2019) An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives. Molecules, 24 (6), 1001, 13 doi:10.3390/molecules24061001.
@article{article, author = {Siber, Tamara and Bu\v{s}i\'{c}, Valentina and Zobund\v{z}ija, Dora and Roca, Sun\v{c}ica and Viki\'{c}-Topi\'{c}, Dra\v{z}en and Vrande\v{c}i\'{c}, Karolina and Ga\v{s}o-Soka\v{c}, Dajana}, year = {2019}, pages = {13}, DOI = {10.3390/molecules24061001}, chapter = {1001}, keywords = {quaternization, nicotinamide, substituted 2-bromoacetophenones, microwave synthesis, antifungal activity}, journal = {Molecules}, doi = {10.3390/molecules24061001}, volume = {24}, number = {6}, issn = {1420-3049}, title = {An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives}, keyword = {quaternization, nicotinamide, substituted 2-bromoacetophenones, microwave synthesis, antifungal activity}, chapternumber = {1001} }
@article{article, author = {Siber, Tamara and Bu\v{s}i\'{c}, Valentina and Zobund\v{z}ija, Dora and Roca, Sun\v{c}ica and Viki\'{c}-Topi\'{c}, Dra\v{z}en and Vrande\v{c}i\'{c}, Karolina and Ga\v{s}o-Soka\v{c}, Dajana}, year = {2019}, pages = {13}, DOI = {10.3390/molecules24061001}, chapter = {1001}, keywords = {quaternization, nicotinamide, substituted 2-bromoacetophenones, microwave synthesis, antifungal activity}, journal = {Molecules}, doi = {10.3390/molecules24061001}, volume = {24}, number = {6}, issn = {1420-3049}, title = {An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives}, keyword = {quaternization, nicotinamide, substituted 2-bromoacetophenones, microwave synthesis, antifungal activity}, chapternumber = {1001} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font