Pregled bibliografske jedinice broj: 989826
The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology
The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology // Pathology, Prevention and Therapeutics of Neurodegenerative Disease / Singh, Sarika ; Joshi, Neeraj (ur.).
Singapur: Springer, 2019. str. 39-48 doi:10.1007/978-981-13-0944-1_4
CROSBI ID: 989826 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology
Autori
Jazvinšćak Jembrek, Maja ; Newberg, Kety ; Šimić, Goran
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Pathology, Prevention and Therapeutics of Neurodegenerative Disease
Urednik/ci
Singh, Sarika ; Joshi, Neeraj
Izdavač
Springer
Grad
Singapur
Godina
2019
Raspon stranica
39-48
ISBN
978-981-13-0943-4
Ključne riječi
p53 ; tau pathology ; amyloid β ; Alzheimer’s disease
Sažetak
Extracellular accumulation of amyloid β peptide and intraneuronal deposition of hyperphosphorylated tau protein are defining clinico-pathological characteristics of Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder. Levels of transcription factor p53, which plays an important role in oxidative stress-induced apoptosis, are also found up-regulated in AD brain. We briefly summarized the major p53-mediated molecular events that contribute to pathological changes in AD, with special emphasis on the progression of tau pathology.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-9730 - Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva (ALZTAUPROTECT) (Šimić, Goran) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Hrvatsko katoličko sveučilište, Zagreb
