Naslov
He effect of statin therapy on the characteristics of coronary artery disease in patients with acute coronary syndrome
(The effect of statin therapy on the characteristics of coronary artery disease in patients with acute coronary syndrome)

Autori
Gulin, D ; Vagic, J Sikic ; Kordic, K ; Vrbanic, L ; Galic, E

Izvornik
Journal of Cardiothoracic Surgery (1749-8090) 8 (2013), S1; 152, 1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
statins, acute coronary syndrome

Sažetak
Background: Statins, in addition to lowering blood lipid levels, also protect the cardiovascular system by improving endothelial dysfunction and producing an antiinflammatory and antithrombotic effect that stabilizes plaques. The aim of this study was to investigate the effect of statin therapy(StTh) on the characteristicsof coronary artery disease(CAD) in acute coronary syndrome (ACS). Methods: The study included 125 patients who were admitted to Department of Cardiovascular Diseases of University Hospital Sveti Duh for ACS in 2012. An analysis was made of the impact of prior treatment with statins on the leading diagnosis, distribution of the CAD and type of lesion. Results: 31 patients (24.8%) were treated with StTh prior to admission. Leading diagnoses for patients previously on StTh were STEMI (39%) and unstable angina (39%), while in the group of patients without StTh the leading diagnosis was STEMI (60%). In patients who were treated with StTh the proximal and middle segment of LAD were the most common locations of stenosis. The frequency of single-vessel, two-vessel and three-vessel CAD was equal amongst both groups, while single-vessel CAD was more frequent in patients without prior StTh. According to ACC/AHA classification, type C lesion was discovered in 41% of patients without StTh and in 26% of patients with StTh. Conclusion: According to the results of studies, 10-20% of patientsexperiencing an ACS were being treated with statins priorto the event. In our study, 24.8% of patients had been onStTh. The number of vessels with lesions was seen withequal frequency amongst patients with and without StTh.This apparent lack of benefit can most likely be explainedby the increased number of risk factors amongst patientson StTh. Another advantageous finding seen in patientspreviously treated with statins was a significantly lowerproportion of total occlusions, especially STEMI

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA