Naslov
Effect of liposome composition on calcium phosphate precipitation

Autori
Erceg, Ina ; Selmani, Atiđa ; Ćurlin, Marija ; Domazet Jurašin, Darija ; Kralj, Damir ; Dutour Sikirić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
14th Greta Pifat Mrzljak International School of Biophysics "ABC of Physics of Life" : Book of abstracts / Delač Marion, Ida ; Vuletić, Tomislav - Zagreb : Institut Ruđer Bošković ; Hrvatsko biofizičko društvo, 2018, 74-74

ISBN
978-953-794124-6

Skup
14th Greta Pifat Mrzljak International School of Biophysics: ABC of physics of life

Mjesto i datum
Split, Hrvatska, 23.08.2018. - 01.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
calcium phosphates ; liposomes

Sažetak
Biomineralization is formation of hard tissues in organisms. From physical-chemical point of view it can be considered as a precipitation/crystallization process of inorganic minerals within the organic matrix and/or confined environments. The liposomes closed lipid bilayers, are typical experimental model of confined environment in which biomineralization can occur. The influence of lipid molecules’ structure or their chemical composition and charge (anionic, cationic, zwitterion), on biomineralization is still not fully understand. The aim of this study is to investigate the influence of three lipids (dimyristoylphosphatidylcholine, DMPC, dimyristoylphosphatidylserine, DMPS and phosphatidylcholine, EPC) with different charge of their polar heads, on CaP precipitation. Two precipitation strategies were investigated: fusion of liposomes loaded with constitutive ions (Ca2+ and HPO42–) and spontaneous precipitation of CaP in the presence of liposomes. DMPS exhibited the strongest influence on the precipitation and transformation of the CaP, in both precipitation systems. The obtained results may contribute to the understanding of the general mechanism of inorganic–organic interactions underlying the biomineralization processes, as well as for materials science.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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