Pregled bibliografske jedinice broj: 984406
NME/NM23/NDPK from unicellular eukaryotes to humans
NME/NM23/NDPK from unicellular eukaryotes to humans // FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts / Szuts, David ; Buday, Laszlo (ur.).
Veszprém, 2018. str. 53-53 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 984406 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
NME/NM23/NDPK from unicellular eukaryotes to humans
Autori
Herak Bosnar, Maja ; Perina, Drago ; Harcet, Matija ; Mikoč, Andreja ; Bago, Ružica ; Deželjin, Martina ; Ćetković, Helena
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts
/ Szuts, David ; Buday, Laszlo - Veszprém, 2018, 53-53
ISBN
978-615-5270-47-5
Skup
FEBS3+ conference "From molecules to living systems"
Mjesto i datum
Siófok, Mađarska, 02.09.2018. - 05.09.2018
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Nm23 ; NME ; NDPK ; metastasis supressors
Sažetak
Nucleoside-diphosphate kinases (NME/Nm23/NDPK) are a family of evolutionary conserved enzymes present in all domains of life. The NDPKs transfer the terminal phosphate from a nucleoside triphosphate (mainly ATP) to all other NDPs. A huge interest for this enzyme started when it was discovered that a gene named nm23-H1 (non-metastatic clone 23, also known as NME1), responsible for suppression of metastasis in murine melanoma, is encoding one of the subunits of NDPK, NDPK A. The NME/Nm23/NDPK family members have been assigned a vast range of biological functions including metastasis suppression although the exact mechanism by which they execute their biological functions still remains to be unraveled. Numerous studies reported that proteins from evolutionary distinct organisms exhibit extraordinary similarity in their structures with their orthologs in mammals. Therefore, it is presumed that they have similar biochemical and biological functions which can, in consequence, serve as a new approach of studying human diseases. We performed a series of biochemical and biological tests which suggest that some of the NME genes/proteins in human are represented by a single ancestral type gene that already possesses many of the functions described in mammals. On the contrary, the NME genes that branched of very early in the evolutionary history seem to have changed significantly during metazoan evolution, and along did their protein function.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( CroRIS)
MZOS-098-0982464-2513 - Uloga gena nm23 u karcinomu pločastog epitela usne šupljine (Herak-Bosnar, Maja, MZOS ) ( CroRIS)
HRZZ-IP-2016-06-4021 - Struktura, funkcija i evolucija proteina Nme6/Nm23-H6 (Nemo6) (Herak-Bosnar, Maja, HRZZ - 2016-06) ( CroRIS)
098-0982913-2478
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Maja Herak Bosnar
(autor)
Matija Harcet
(autor)
Ružica Bago
(autor)
Helena Ćetković
(autor)
Andreja Mikoč
(autor)
Martina Deželjin
(autor)