Naslov
Characterization of dispersed alpha-satellite DNA elements in human genome

Autori
Zorić, Doris

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Prirodoslovno-matematički fakultet

Mjesto
Zagreb

Datum
13.02

Godina
2018

Stranica
51

Mentor
Ugarković, Đurđica

Neposredni voditelj
Feliciello, Isidoro

Ključne riječi
alpha satellite DNA ; cis-regulatory elements ; insertion polymorphism ; adaptation to heat stress

Sažetak
Satellite DNAs are tandemly repeated sequences present in long uninterupted arrays in genetically silenced heterochromatic regions. Genome sequencing projects revealed the presence and the distribution of repetitive satellite DNA in the vicinity of genes, or in other words, the dispersion of satellite DNA elements across the euchromatic portion of genome. The presence of functional elements such as promoters and transcription factors binding sites within a number of satelites led to assumption that satellite DNAs may act as gene expression cis-regulatory elements. The main goal of this research is to determine the abundance and the distribution of dispersed elements of alpha satellite DNA in human genome and to propose them as genetic polymorphisms in the population, as well as to investigate the potential regulatory role of those elements by DNA methylation analysis before and after the heat-shock treatment.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA