Naslov
DOG MAMMARY TUMOUR PHOSPHOLIPID FATTY ACID PROFILE: POSSIBLE IMPLICATIONS FOR TUMOUR GRADING AND PROGNOSIS

Autori
Severin, Krešimir ; Mašek, Tomislav ; Šoštarić-Zuckerman, Ivan ; Maurić, Maja ; Musulin, Andrija ; Vnuk, Dražen ; Vince, Silvijo ; Džaja, Petar ; Starčević, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of comparative pathology / - , 2018, 130-130

Skup
Joint ESVP and ECVP Congress

Mjesto i datum
Cluj-Napoca, Rumunjska, 05.09.2018. - 08.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Mammary tumor, Fatty acids, Tumor grading, Dogs

Sažetak
Introduction: During cancer pathogenesis, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism have been accepted as a major metabolic pathway feature of solid tumours. Attempts to understand the role of different lipids in cancer physiology depend on the ability to accurately monitor alterations in lipid composition at the cellular level, due to the diversity of lipid classes. Mammary gland tumours are common in companion animal medicine. We investigated the differences in total and phospholipid fatty acid composition of tumour and normal tissue samples in an attempt to obtain a better insight into the lipid metabolism of tumour cells, as well as to improve grading of studied tumours. Materials andMethods: Paired samples of tumour and adjacent nontumour tissuewere isolated from37 mammary tumours.After histopathological examination, the fatty acid profile was determined by GC-MS. Results: The mammary tumour tissue showed significant differences compared with the normal tissue. The most significant differences were increased content of C20:4n6, 18:1n7, 20:3n6, C22:4n6 and C22:5n6. Conclusions: The results of this study showed significant variations in fatty acid profile between tumour and non-tumour tissue with respect to different lipid classes.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA