Naslov
Protective effect of grape seed proanthocyanidins on drug-induced oxidative stress in rat

Autori
Oršolić, Nada ; Odeh, Dyana

Izvornik
International Journal of Medical Research and Pharmaceutical Sciences (2394-9414) 6 (2019), 1; 1-21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Retinoic acidinduced osteoporosis ; Proanthocyanidins ; Bone remodeling markers ; Bone mineral density ; Oxidative/Antioxidative status.

Sažetak
Several drugs, including 13 cis-retinoic acid (13cRA) are producing reactive oxygen species that may be responsible for the toxicity and harmful adverse effects on bone and other tissues. The present study investigates the antiosteoporotic effects of grape seed proanthocyanidins (GSPs) in a 13cRA-induced osteoporosis model of rats and healthy rats. Y59 rats were given GSPs (100 mg kg-1 ) or alendronate (40 mg kg-1, a positive control) concomitant with 13cRA (80 mg kg-1) once daily for 14 days by a single intragastric application. Twenty four hours after the treatment, we analysed bone turnover serum biochemical markers, such as: osteocalcin (OC), C- terminal fragment of type I collagen (CTX), bone mineral density (BMD), calcium and phosphorus content, geometrical and physical parameters of bone as well as oxidative stress parameters, haematological and biochemical parameters in peripherial blood. The treatment with GSPs increased BMD, OC level, femoral geometric characteristics, Ca and P content (P=0.025 ; P=0.025) in 13cRA-induced bone loss model. In addition, GSPs- treated rats had significantly lower serum ALP activity (P<0.001) and malondialdehyde (MDA) levels in both liver and kidney (P<0.05). Histological results showed its protective action as well, through promotion of bone formation. According result GSPs could have similar protective action on bone health in humans.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti

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