Naslov
Risk factors of hepatocellular carcinoma recurrence after liver transplantation

Autori
Dinjar Kujundžić, Petra ; Ostojić, Ana ; Mijić, Maja ; Jelić, Ana ; Sobočan, Nikola ; Lalovac, Miloš ; Kunac, Nino ; Ilić, Diana ; Borčić, Tina ; Bogadi, Ivan ; Mišetić Dolić, Zrinka ; Škurla, Bruno ; Mrzljak, Anna ; Kocman, Branislav ; Vidjak, Vinko ; Gašparov, Slavko ; Filipec Kanižaj, Tajana.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the First European Conference of Young Gastroenterologist “Challenges in clinical gastroenterology and hepatology” / Mikolašević Ivana, Bokun Tomislav - Zagreb, 2018, 130-131

Skup
1st European Conference of Young Gastroenterologists: Challenges in Clinical Gastroenterology and Hepatology (ECYG)

Mjesto i datum
Zagreb, Hrvatska, 06.12.2018. - 09.12.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hepatocellular carcinoma ; liver transplantation ; risk factors ; survival recurrence

Sažetak
INTRODUCTION Hepatocellular carcinoma (HCC) is the fastest growing indication for liver transplantation (LT) worldwide.1 The expected five-year survival rates of LT for HCC meeting conventional Milan criteria are 65%–80% and they are influenced by tumor recurrence.2 AIM The aim of the study was to analyze risk factors for HCC recurrence and 5-year rate survival in patients who underwent LT for HCC. T MATERIALS AND METHODS his retrospective study included 198 patients who underwent LT for HCC between 2006 and 2018 in University hospital Merkur. Pre- and post- transplant data was tested using univariate analysis (UA) and multivariate analysis (MA) to assess variables influencing HCC recurrence and 5- year survival rate. RESULTS The five-year HCC recurrence rate was 11%. After UA, risk factors for HCC recurrence were: HCC beyond Milan criteria (MC) based on surgical specimen (SS), more than 3 HCC lesions on SS, total tumor diameter >9cm, micro- and macro- vascular invasion of HCC. Following MA, only total tumor diameter > 9 cm remained independent risk factors for recurrence of HCC. The five-year survival rate was 81%. Median of follow up was 37 months. Based on UA, risk factors for 5-year mortality were: age >60 years, HCC beyond MC based on SS, more than 3 HCC lesions in SS, AFP >1000 ng/mL, micro- and macro- vascular invasion and recurrence of HCC. After MA, independent risk factors were age >60, more than 3 HCC lesions and recurrence of HCC (OR 1.07, 1.09 and 3.62, CI 95 %, respectively). CONCLUSION Patients after LT for HCC have good prognosis with more than 80% 5-year survival and 11% HCC recurrence rate. Total HCC diameter > 9 cm, measured on surgical specimen, is the only independent risk factors for the recurrence of HCC. Furthermore, recurrence of tumor is most significant risk factor for the 5- year mortality. Other risk morality factors are recipient age > 60 and more than 3 HCC lesions on surgical specimen.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA