Naslov
Diagnostic accuracy of multiphasic contrast CT for hepatocellular carcinoma in liver transplant recipients

Autori
Ostojić, Ana ; Dinjar Kujundžić, Petra ; Mijić, Maja ; Jelić, Ana ; Sobočan, Nikola ; Lalovac, Miloš ; Kunac, Nino ; Ilić, Diana ; Borčić, Tina ; Bogadi, Ivan ; Mišetić Dolić, Zrinka ; Škurla, Bruno ; Mrzljak, Anna ; Vidjak, Vinko ; Branislav, Kocman ; Filipec Kanižaj, Tajana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, znanstveni

Izvornik
Book of abstracts of the the First European Conference of Young Gastroenterologist “Challenges in clinical gastroenterology and hepatology” / - , 2018, 44-45

Skup
1st European Conference of Young Gastroenterologists: Challenges in Clinical Gastroenterology and Hepatology (ECYG)

Mjesto i datum
Zagreb, Hrvatska, 06.12.2018. - 09.12.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
HCC ; CT ; TACE

Sažetak
Introduction: Hepatocellular carcinoma (HCC) is unique among malignancies in having tumor characteristics on cross-sectional multiphasic contrast computed tomography (CT) or magnetic resonance imaging that allow for a highly accurate diagnosis of HCC without an invasive biopsy.1 Aim of this study was to present accuracy of CT in diagnosis of HCC in liver transplant recipients in our setting. Patients and methods: In this retrospective study we evaluated data of 187 patients with HCC who underwent deceased donor liver transplantation (LT) from 2006 to September 2018 in the University Hospital Merkur, Croatia. The correlation between preoperative CT findings and surgical specimens (SS) in diagnosis of HCC was analyzed. Milan criteria (MC) and number of HCC nodules (NHN) were used. Patients were divided in 2 groups: In TACE (transarterial chemoembolization) group 35 patients were down- staged to within acceptable criteria before LT and nonTACE group had 152 patients who were not treated with TACE. Results: In nonTACE group CT correctly identified HCC within MC in 70% patients. In 24% of patients CT underestimated HCC and in 6% overestimated HCC regarding MC. Sensitivity and specificity of CT were 90% and 35.5%, with accuracy of 70.4%. In 39% patients CT was in accordance with SS regarding NHN, while in 49% patients NHN were underestimated and in 11% overestimated. 18 (51%) patients in TACE group considered had HCC within MC that was correctly identified by CT. In that group CT underestimated HCC using MC in 40% patients and overestimated in 9%. Sensitivity and specificity of CT were 82.4% and 22.2% with accuracy of 51.4%. CT correctly determined NHN after TACE in 19% of patients, making sensitivity 96%, specificity 0% and accuracy 66.7%. Conclusion: Multiphasic contrast CT demonstrated better accuracy for HCC evaluation in patients who are not treated with TACE. However, due to relatively low CT accuracy for Milan criteria a critical appraisal of patient characteristics is recommended to determine candidacy for transplantation. 1 Manini MA, Sangiovanni A, Fornari F, Piscaglia F, Biolato M, Fanigliulo L, et al. Clinical and economical impact of 2010 AASLD guidelines for the diagnosis of hepatocellular carcinoma. J Hepatol 2014 ; 60:995-100)

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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