Naslov
Platelet serotonin concentrations and depressive symptoms of schizophrenia

Autori
Peitl, Vjekoslav ; Silić, Ante ; Ostojić, Draženka ; Kovak Mufić, Ana ; Crnković, Danijel ; Karlović, Dalibor

Izvornik
Npj Schizophrenia (2334-265X) 2016 (2016); 11-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, znanstveni

Ključne riječi
platelet serotonin ; depressive symptoms ; schizophrenia

Sažetak
Background: Depressive symptoms seem to be frequent in schizophrenia, but so far have received less attention than other symptom domains. Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. The objectives of this study were to investigate platelet serotonin concentrations in schizophrenic patients with and without depressive symptoms, as well as to investigate the association of platelet serotonin concentrations with symptoms of schizophrenia, mostly depressive symptoms. Methods: A total of 364 patients were included in the study. Significant depressive symptoms were defined by the cut-off score of 7 or more on Calgary Depression Rating Scale (CDSS). Platelet serotonin concentrations were assessed by the enzyme-linked immunosorbent assay (ELISA). Results: Prevalence of depression in patients with schizophrenia was 65.1%. Schizophrenic patients with depressive symptoms showed lower platelet serotonin concentrations compared to schizophrenic patients without depressive symptoms. An inverse correlation was found between platelet serotonin and depressive symptoms, with those symptoms being associated with lower platelet serotonin concentrations in patients with depressive symptoms compared to patients without depressive symptoms. Discussion: Depressive symptoms in schizophrenic patients may be associated with reduced concentrations of platelet serotonin.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA