Naslov
Citrinin in endemic nephropathy

Autori
Čulig, Borna ; Ban, Božica ; Peić, Ana ; Momirović, Aleksandar ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstracts of the 2nd International Congress on Food Safety and Quality “Food Life Cycle” / Šostar, Zvonimir ; Šikić, Sandra ; Krivohlavek, Adela - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2018, 57-57

Skup
2. međunarodni kongres o sigurnosti i kvaliteti hrane = 2nd International Congress on Food Safety and Quality

Mjesto i datum
Opatija, Hrvatska, 13.11.2018. - 16.11.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Balkan endemic nephropathy ; ELISA ; mycotoxins ; spot urine

Sažetak
Balkan endemic nephropathy (BEN) is a tubulo- interstitial nephropathy associated with upper urinary tract cancers. Recently it was confirmed that aristolochic acid is a causative agent and BEN is considered an environmental form of aristolochic acid nephropathy. Citrinin (CTN) is a mycotoxin produced by several species of the genera Aspergillus, Monascus, and Penicillium and occurs mainly in stored grains. It was speculated that mycotoxins might play an additive role to aristolochic acid in etiophatogenesis of BEN. So far, that claim has not yet been proven. The aim of this study was to analyse urine CTN concentrations in residents of endemic villages. In this study we enrolled 38 patients who were diagnosed with BEN and another 38 subjects from non-endemic villages as the control. CTN was determined in spot urine by ELISA (enzyme-linked immunosorbent assay). For the statistical analysis of the data we used Student’s t-test. Our preliminary data show that CTN urine concentrations is higher in BEN than in non-BEN households, which might indicate poorer storage of harvested grain. This result should be confirmed on a larger number of subjects to determine the putative role of CTN in the etiophatogenesis of BEN.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA