Naslov
Monitoring of sulfonamides, macrolides and other pharmaceuticals in surface waters in Croatia

Autori
Žuntar, Irena ; Krivohlavek, Adela ; Ivešić, Martina ; Tolic, Sonja ; Šikic, Sandra ; Musić, Valerija ; Pavlić, Ivan ; Bursik Andrea ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmaceutical Regulatory Affairs: Open Access / - Frankfurt, 2018, 73-73

Skup
15th Annual European Pharma Congress

Mjesto i datum
Frankfurt na Majni, Njemačka, 07.05.2018. - 09.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sulfonamides ; macrolides ; pharmaceuticals ; surface water

Sažetak
Sulfonamides, macrolides, torasemide, fumagillin and chloramphenicol were simultaneously analyzed in surface water samples by using solid-phase extraction (SPE) and reversed-phase (RP) liquid chromatography- electrospray tandem mass spectrometry (LC-ESI- MS/MS). In the pre- concentration and clean-up process, the pH value of samples and volume of the solvent for extraction of analytes from cartridge were optimized. Extraction recoveries were high with values in the range from 62 to 115%. Limits of quantification (LoQ) were in the range from 0.02 µg/L–0.2 µg/L. Repeatability of the method was evaluated at LoQ and expressed as relative standard deviation (RSD). Calculated RSDs were low with values in the range from 2.4 to 14.5%. The method was successfully applied for analysis of the real samples of surface waters. Samples were collected along the rivers in Croatia on 19 sampling sites in Danube and Adriatic catchment areas in 2013, and another 20 places in 2014. Altogether, 20 target compounds were analyzed in 362 water samples and detected in 24 samples in the range, 0.02–5.3 µg/L or in 6.6% of samples. The most frequent and highest concentrations were detected for macrolide antibiotics. This is the first attempt of monitoring of antibiotics in surface waters in Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Javno zdravstvo i zdravstvena zaštita, Farmacija

POVEZANOST RADA