Pregled bibliografske jedinice broj: 97350
MHC II-independent CD4+ T cells facilitate induction of colitis in immunodeficient RAG-/-HOSTS
MHC II-independent CD4+ T cells facilitate induction of colitis in immunodeficient RAG-/-HOSTS // Abstracts of the Joint Annual Meeting 2000 of the German and Dutch Societies of Immunology ; u: Immunobiology 203 (2000) 1/3
Düsseldorf, Njemačka, 2000. str. 520-520 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
MHC II-independent CD4+ T cells facilitate induction of colitis in immunodeficient RAG-/-HOSTS
Autori
Trobonjača, Zlatko ; Leithaeuser, Frank ; Moeller, Peter ; Bluethmann, Horst ; Koezuka, Yasuhiko ; MacDonald, Robson ; Reimann, Joerg
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts of the Joint Annual Meeting 2000 of the German and Dutch Societies of Immunology ; u: Immunobiology 203 (2000) 1/3
/ - , 2000, 520-520
Skup
Joint Annual Meeting of the German and Dutch Societies of Immunology
Mjesto i datum
Düsseldorf, Njemačka, 29.11.2000. - 02.12.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Sažetak
CD4(+) alpha beta T cells from either normal C57BL/6 (B6) or MHC-II-deficient (A alpha(-/-) or A beta(-/-)) B6 donor mice engrafted into congenic immunodeficient RAG1(-/-) B6 hosts induced an aggressive inflammatory bowel disease (IBD). Furthermore, CD4(+) T cells from CD1d(-/-) knockout (KO) B6 donor mice but not those from MHC-I(-/-) (homozygous transgenic mice deficient for beta(2)-microglobulin) KO B6 mice induced a colitis in RAG(-/-) hosts. Abundant numbers of in vivo activated (CD69(high)CD44(high)CD28(high)) NK1(+) and NK1(-) CD4(+) T cells were isolated from the inflamed colonic lamina propria (cLP) of transplanted mice with IBD that produced large amounts of TNF-alpha and IFN-gamma but low amounts of IL-4 and IL-10. IBD-associated cLP Th1 CD4(+) T cell populations were polyclonal and MHC-II-restricted when derived from normal B6 donor mice, but oligoclonal and apparently MHC-I-restricted when derived from MHC-II-deficient (A alpha(-/-) or A beta(-/-)) B6 donor mice. cLP CD4(+) T cell populations from homozygous transgenic mice deficient for beta(2)-microglobulin KO B6 donor mice engrafted into RAG(-/-) hosts were Th2 and MHC-II restricted. These data indicate that MHC-II-dependent as well as MHC-II-independent CD4(+) T cells can induce a severe and lethal IBD in congenic, immunodeficient hosts, but that the former need the latter to express its IBD-inducing potential.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
