Naslov
FOOD SUPPLEMENTS ADULTERATED WITH ERECTILE DYSFUNCTION DRUGS - PHARMACOLOGICAL AND TOXICOLOGICAL HEALTH RISK

Autori
Žuntar, Irena ; Krivohlavek A ; Putnik, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 2nd International Congress on Food Safety and Quality "Food Life Cycle", Arhiv za higijenu rada i toksikologiju 2018 ; 69 (Suppl. 1) / Šostar, Zvonimir ; Šikić, Sandra ; Krivohlavek, Adela - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2018, 20-20

Skup
2. međunarodni kongres o sigurnosti i kvaliteti hrane = 2nd International Congress on Food Safety and Quality

Mjesto i datum
Opatija, Hrvatska, 13.11.2018. - 16.11.2018

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
dietary supplements ; herbal remedies ; phosphodiesterase type 5 inhibitors ; public health risk ; sildenafil

Sažetak
The use of herbal remedies and dietary supplements has greatly increased worldwide. Survey based on EU rapid alert system for food and feed (RASFF) showed adulterations of plant food supplements (PFSs) with a complex range of foreign substance. Among the most frequently noticed were sildenafil and its analogues that are classified as phosphodiesterase type 5 inhibitors (PDE5Is). Sildenafil with vardenafil, tadalafil, avanafil, udenafil, mirodenafil, lodenafil are best-known compounds intended for medical treatments of erectile dysfunction (ED). Although all PDE5Is drugs are similar in mechanism of action, their pharmacokinetics differs. Even though the addition of PDE5Is or theirs analogues are forbidden in foods and dietary supplements, they are widely available on the (illegal) markets. This includes Internet stores and sales of various undeclared adulterants in PFSs. Because of falsely declared formulation of PFSs, they are often advertised as being “natural.” Hence, many consumers perceive these products as being “healthier” and safer in comparison to the conventional pharmaceuticals. PFSs adulterated with analogues pose a pharmacological and toxicological health risk as unapproved analogues are mostly of unknown pharmacokinetics and safety profile. Thus, putting consumers’ lives at risk from different drug-drug and herbal-drug interactions with unpredicted adverse effects. Therefore, to protect public health it is necessary to enforce legal measures supported by the adequate analytical methods and monitoring of the markets. Additionally, it is critical to inform public of possible health risks. This needs involvement of government, law enforcement, media, medical and pharmaceutical professions and others.

Izvorni jezik
Engleski

POVEZANOST RADA