Naslov
Visual function in multiple sclerosis

Autori
Kaštelan, Snježana ; Gverović Antunica, Antonela ; Lazibat, Ines ; Bakija, Ivana ; Bogadi, Marija ; Pili, Kristijan ; Kasun, Ema

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the 2018 OCCSEE & EAOO Conference / - , 2018, 152-152

Skup
2018 Optometry Conference of Central and South-Eastern Europe (OCCSEE) & European Academy of Optometry and Optics (EAOO)

Mjesto i datum
Pula, Hrvatska, 11.05.2018. - 13.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Visual impairment ; multiple sclerosis ; optic neuritis

Sažetak
Educational topic: Visual impairment which is most often caused by acute optic neuritis (ON) is one of the important symptoms of multiple sclerosis (MS). Although ON is very common, even in 20% of cases presenting manifestation of MS, visual deficits and structural loss of neural axons can occur in asymptomatic eyes. Discussion: Awareness of visual dysfunction in MS is increasing partially due to the development of sensitive visual function tests, structural markers such as optical coherence tomography (OCT) and quality of life (QOL) assessment which enable us to verify correlations between clinical symptoms and signs to the structural and functional changes of the afferent visual pathway. OCT enables high- resolution reconstructions of retinal anatomy and allows detailed analysis of the retinal nerve fiber layer (RNFL) as well as ganglion cells. Axonal and neuronal degeneration are important features of MS and OCT assessment allows quantification of ganglion cell and neuronal layer loss and axonal degeneration in MS in vivo making the anterior visual pathway and acute ON valuable models for testing novel agents for neuroprotection and repair. New therapies that reduce axonal loss by neuroprotective or myelin repair mechanisms can now be assessed non- invasively by OCT and linked with visual function data. Longitudinal studies with OCT monitoring have shown RNFL axonal loss over time that occurs even in the absence of acute ON and is associated with clinically important worsening of vision and QOL, even in patients with benign MS. Conclusions: Ophthalmological assessment and new diagnostic methods such as OCT will improve our understanding the mechanisms of brain tissue damage in MS and thus emphasize the importance of visual function as a model for evaluation in medical practice and clinical trials in MS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA