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Pregled bibliografske jedinice broj: 971230

Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians

Matana, Antonela; Popović, Marijana; Boutin, Thibaud; Torlak, Vesela; Brdar, Dubravka; Gunjača, Ivana; Kolčić, Ivana; Boraska Perica, Vesna; Punda, Ante; Polašek, Ozren et al.
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians // Genomics, 111 (2019), 4; 737-743 doi:10.1016/j.ygeno.2018.04.012. (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 971230 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians

Autori
Matana, Antonela ; Popović, Marijana ; Boutin, Thibaud ; Torlak, Vesela ; Brdar, Dubravka ; Gunjača, Ivana ; Kolčić, Ivana ; Boraska Perica, Vesna ; Punda, Ante ; Polašek, Ozren ; Hayward, Caroline, Barbalić, Maja ; Zemunik, Tatijana

Izvornik
Genomics (0888-7543) 111 (2019), 4; 737-743

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Genome-wide association study ; Meta-analysis ; Thyroid antibody ; Thyroglobulin ; Thyroid peroxidase ; Single nucleotide polymorphism

Sažetak
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta- analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta- analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, P = 7.76 × 10−9). The same locus had borderline association with TPOAb levels in females (rs1935377, P = 8.58 × 10−8). In conclusion, we identified a novel gender specific locus associated with TgAb and TPOAb levels. Our findings provide a novel insight into genetic and gender differences associated with thyroid antibodies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
HRZZ 1498

Ustanove:
KBC Split,
Medicinski fakultet, Split

Profili:

Avatar Url Ivana Gunjača (autor)

Avatar Url Antonela Matana (autor)

Avatar Url Vesela Torlak (autor)

Avatar Url Tatijana Zemunik (autor)

Avatar Url Marijana Popovic (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Vesna Boraska Perica (autor)

Avatar Url Ivana Kolčić (autor)

Avatar Url Ante Punda (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Matana, Antonela; Popović, Marijana; Boutin, Thibaud; Torlak, Vesela; Brdar, Dubravka; Gunjača, Ivana; Kolčić, Ivana; Boraska Perica, Vesna; Punda, Ante; Polašek, Ozren et al.
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians // Genomics, 111 (2019), 4; 737-743 doi:10.1016/j.ygeno.2018.04.012. (međunarodna recenzija, članak, znanstveni)
Matana, A., Popović, M., Boutin, T., Torlak, V., Brdar, D., Gunjača, I., Kolčić, I., Boraska Perica, V., Punda, A. & Polašek, O. (2019) Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians. Genomics, 111 (4), 737-743 doi:10.1016/j.ygeno.2018.04.012..
@article{article, author = {Matana, Antonela and Popovi\'{c}, Marijana and Boutin, Thibaud and Torlak, Vesela and Brdar, Dubravka and Gunja\v{c}a, Ivana and Kol\v{c}i\'{c}, Ivana and Boraska Perica, Vesna and Punda, Ante and Pola\v{s}ek, Ozren and Zemunik, Tatijana}, year = {2019}, pages = {737-743}, DOI = {10.1016/j.ygeno.2018.04.012.}, keywords = {Genome-wide association study, Meta-analysis, Thyroid antibody, Thyroglobulin, Thyroid peroxidase, Single nucleotide polymorphism}, journal = {Genomics}, doi = {10.1016/j.ygeno.2018.04.012.}, volume = {111}, number = {4}, issn = {0888-7543}, title = {Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians}, keyword = {Genome-wide association study, Meta-analysis, Thyroid antibody, Thyroglobulin, Thyroid peroxidase, Single nucleotide polymorphism} }
@article{article, author = {Matana, Antonela and Popovi\'{c}, Marijana and Boutin, Thibaud and Torlak, Vesela and Brdar, Dubravka and Gunja\v{c}a, Ivana and Kol\v{c}i\'{c}, Ivana and Boraska Perica, Vesna and Punda, Ante and Pola\v{s}ek, Ozren and Zemunik, Tatijana}, year = {2019}, pages = {737-743}, DOI = {10.1016/j.ygeno.2018.04.012.}, keywords = {Genome-wide association study, Meta-analysis, Thyroid antibody, Thyroglobulin, Thyroid peroxidase, Single nucleotide polymorphism}, journal = {Genomics}, doi = {10.1016/j.ygeno.2018.04.012.}, volume = {111}, number = {4}, issn = {0888-7543}, title = {Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians}, keyword = {Genome-wide association study, Meta-analysis, Thyroid antibody, Thyroglobulin, Thyroid peroxidase, Single nucleotide polymorphism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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