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Pregled bibliografske jedinice broj: 970686

Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications

Moshtagh, PR; Rauker, J; Sandker, MJ; Zuiddam, MR; Dirne, FW; Klijnstra, E; Duque L, Steendam, R; Weinans, H; Zadpoor, AA
Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications // Journal of the Mechanical Behavior of Biomedical Materials, 34 (2014), 313-319 doi:10.1016/j.jmbbm.2014.03.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications

Autori
Moshtagh, PR ; Rauker, J ; Sandker, MJ ; Zuiddam, MR ; Dirne, FW ; Klijnstra, E ; Duque L, Steendam, R ; Weinans, H ; Zadpoor, AA

Izvornik
Journal of the Mechanical Behavior of Biomedical Materials (1751-6161) 34 (2014); 313-319

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nanoindentation, Mechanical properties, Monodisperse microspheres

Sažetak
Biodegradable polymeric microspheres are interesting drug delivery vehicles for site- specific sustained release of drugs used in treatment of osteoarthritis. We study the nano- mechanical properties of microspheres composed of hydrophilic multi-block copolymers, because the release profile of the microspheres may be dependent on the mechanical interactions between the host tissues and the microspheres that aim to incorporate between the cartilage surfaces.Three different sizes of monodisperse microspheres, namely5, 15, and 30 μm, were tested in both dry and hydrated(swollen)states.Atomic force microscopy was used for measuring nanoindentation-based force– displacement curves that were later used for calculating the Young's moduli using the Hertz's contact theory.For every microsphere size and condition, the measurements were repeated 400–500 times at different surface locations and the histograms of theYoung's modulus were plotted.The mean Young's modulus of 5, 15, and30 μm microspheres were respectively 56.1771.1(mean7SD), 94.67103.4, and57.6758.6MPa under dry conditions and226.4754.2, 334.57128.7, and 342.57136.8kPa in the swollen state.The histograms were not represented well by the average Young's modulus and showed three distinct peaks in the dry state and one distinct peak in the swollen state.The peaks under dry conditions are associated with the different parts of the co- polymeric material at the nano- scale.The measured mechanical properties of swollen microspheres are within the range of the nano- scale properties of cartilage, which could favor integration of the microspheres with the host tissue.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija



POVEZANOST RADA

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Moshtagh, PR; Rauker, J; Sandker, MJ; Zuiddam, MR; Dirne, FW; Klijnstra, E; Duque L, Steendam, R; Weinans, H; Zadpoor, AA
Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications // Journal of the Mechanical Behavior of Biomedical Materials, 34 (2014), 313-319 doi:10.1016/j.jmbbm.2014.03.002 (međunarodna recenzija, članak, znanstveni)
Moshtagh, P., Rauker, J., Sandker, M., Zuiddam, M., Dirne, F., Klijnstra, E., Duque L, Steendam, R, Weinans, H. & Zadpoor, A. (2014) Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications. Journal of the Mechanical Behavior of Biomedical Materials, 34, 313-319 doi:10.1016/j.jmbbm.2014.03.002.
@article{article, author = {Moshtagh, PR and Rauker, J and Sandker, MJ and Zuiddam, MR and Dirne, FW and Klijnstra, E and Weinans, H and Zadpoor, AA}, year = {2014}, pages = {313-319}, DOI = {10.1016/j.jmbbm.2014.03.002}, keywords = {Nanoindentation, Mechanical properties, Monodisperse microspheres}, journal = {Journal of the Mechanical Behavior of Biomedical Materials}, doi = {10.1016/j.jmbbm.2014.03.002}, volume = {34}, issn = {1751-6161}, title = {Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications}, keyword = {Nanoindentation, Mechanical properties, Monodisperse microspheres} }
@article{article, author = {Moshtagh, PR and Rauker, J and Sandker, MJ and Zuiddam, MR and Dirne, FW and Klijnstra, E and Weinans, H and Zadpoor, AA}, year = {2014}, pages = {313-319}, DOI = {10.1016/j.jmbbm.2014.03.002}, keywords = {Nanoindentation, Mechanical properties, Monodisperse microspheres}, journal = {Journal of the Mechanical Behavior of Biomedical Materials}, doi = {10.1016/j.jmbbm.2014.03.002}, volume = {34}, issn = {1751-6161}, title = {Nanomechanical properties of multi-block copolymer microspheres for drug delivery applications}, keyword = {Nanoindentation, Mechanical properties, Monodisperse microspheres} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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