Pregled bibliografske jedinice broj: 970677
Characterisation of the integrin αV-dependent adhesome in MDA-MB-435S melanoma cells
Characterisation of the integrin αV-dependent adhesome in MDA-MB-435S melanoma cells // A COST Action CA15214 WG1-WG2-WG3-WG4 Networking Meeting " Mechanobiology of cells and tissues" / Andjus, Pavle ; Ambriović-Ristov, Andreja ; Travasso, Rui ; Saraiva, Nuno ; Liović, Mirjana (ur.).
Ljubljana, 2018. str. 8-8 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 970677 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Characterisation of the integrin αV-dependent adhesome in MDA-MB-435S melanoma cells
Autori
Paradžik, Mladen ; Humphries ; Jonathan D., Nestić, Davor ; Majhen, Dragomira ; Dekanić, Ana ; Stojanović, Nikolina ; Sedda, Delphine ; Weber, Igor ; Humphries, Martin J. ; Ambriović-Ristov, Andreja
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
A COST Action CA15214 WG1-WG2-WG3-WG4 Networking Meeting " Mechanobiology of cells and tissues"
/ Andjus, Pavle ; Ambriović-Ristov, Andreja ; Travasso, Rui ; Saraiva, Nuno ; Liović, Mirjana - Ljubljana, 2018, 8-8
Skup
A COST Action CA15214 Networking Meeting "Mechanobiology of cells and tissues in health and disease"
Mjesto i datum
Ljubljana, Slovenija, 08.11.2018. - 09.11.2018
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
breast cancer ; melanoma ; integrins ; adhesome
Sažetak
Integrins are heterodimeric glycoproteins consisted of α and β subunits that binds cells to extracellular matrix proteins. Upon integrin clustering, proteins are recruited to form multimolecular integrin adhesion complexes (IACs) that facilitate the linkage between integrins and the actin cytoskeleton and to permit bidirectional signalling. The αv integrin is expressed in most tumour cells where it regulates a diverse array of cellular functions. The aim of our work was to assess changes in IAC composition in melanoma cell line MDA-MB-435S in order to better understand beneficial effects of integrin αv knockdown in melanoma therapy.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Projekti:
IP-2013-11-2465 - Molekularni mehanizmi povećanja osjetljivosti na protutumorske lijekove stanica karcinoma dojke i melanoma čovjeka utišavanjem integrina (INSILCELL) (Ambriović Ristov, Andreja, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Dragomira Majhen
(autor)
Mladen Paradžik
(autor)
Igor Weber
(autor)
Andreja Ambriović Ristov
(autor)
Nikolina Stojanović
(autor)
Ana Tadijan
(autor)