Pregled bibliografske jedinice broj: 969663
Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells
Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells // Cells, 7 (2018), 6; 58-70 doi:10.3390/cells7060058 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 969663 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells
Autori
Horvat, Luka ; Antica, Mariastefania ; Matulić, Maja
Izvornik
Cells (2073-4409) 7
(2018), 6;
58-70
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
B and T leukemia cell line ; Notch ; PARP1 ; Ikaros ; Jagged ; gene expression
Sažetak
Differentiation of blood cells is one of the most complex processes in the body. It is regulated by the action of transcription factors in time and space which creates a specific signaling network. In the hematopoietic signaling system, Notch is one of the main regulators of lymphocyte development. The aim of this study was to get insight into the regulation of Notch signalization and the influence of poly(ADP-ribose)polymerase (PARP) activity on this process in three leukemia cell lines obtained from B and T cells. PARP1 is an enzyme involved in posttranslational protein modification and chromatin structure changes. B and T leukemia cells were treated with Notch and PARP inhibitors, alone or in combination, for a prolonged period. The cells did not show cell proliferation arrest or apoptosis. Analysis of gene and protein expression set involved in Notch and PARP pathways revealed increase in JAGGED1 expression after PARP1 inhibition in B cell lines and changes in Ikaros family members in both B and T cell lines after γ-secretase inhibition. These data indicate that Notch and PARP inhibition, although not inducing differentiation in leukemia cells, induce changes in signaling circuits and chromatin modelling factors.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Antica, Mariastefania, MZOS ) ( CroRIS)
119-0000000-3172 - Poli(ADPribozilacija, starenje i plazminogenska aktivacija u tumorskim stanicama (Matulić, Maja, MZOS ) ( CroRIS)
HRZZ-IP-2013-11-7140 - Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija (NOBLE) (Antica, Mariastefania, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
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