Naslov
Does A Single Dose Of Systemic Antibiotic Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial

Autori
Kotarac Knežević, Ana ; Knežević, Dinko ; Granić, Marko ; Kuna, Tihomir ; Grgić, Nino ; Gabrić, Dragana

Izvornik
Research journal of pharmaceutical, biological and chemical sciences (0975-8585) 9 (2018), 6; 1223-1233

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
umnjak ; intraoralni operativni zahvati ; postoperativne komplikacije ; antibiotska profilaksa ; placebo učinak
(third molar ; oral surgical procedures ; postoperative complications ; antibiotic prophylaxis ; placebo effect)

Sažetak
This study evaluates the effectiveness of a prophylactic single preoperative dose of amoxicillin in decreasing complications after lower third molar surgery. This study consisted of 400 patients indicated for third molar surgery who were randomly divided in two groups (200 patients per group). The first group of patients had never been diagnosed pericoronal inflammation while the second group consisted of patients with preoperative pericoronal inflammation. The both groups were divided in tested and control subgroups (100 patients per group). The tested subgroup received a prophylactic single dose of 2g amoxicillin one hour prior to the procedure. The second control subgroup received a placebo. Complications including swelling, alveolar osteitis, infection, limited mouth opening, pain, bleeding, and increased body temperature were evaluated postoperatively. The results of placebo subgroup within the first group were: a more statistically significant first degree swelling within 24 hours (P=0.048). The results of placebo subgroup within the second group were: pain intensity after seven days was significantly more intense (P=0.001) and the average duration of pain was significantly longer. Prophylactic dose of amoxicillin have a benefical effect on postoperative complications and can be recommended as a routine method in healthy patients with previous inflammation.

Izvorni jezik
Hrvatski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA