Naslov
Expression profiles of P53/P73 isoforms in human melanoma cell lines

Autori
Slade, Neda ; Hanžić, Nikolina ; Radić, Martina ; Ozretić, Petar ; Petrović, Lidija ; Jazvinšćak Jembrek, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, in ESMO Open, Volume 3, Supplement 2 / Berns, Anton - London : Delhi : European Society for Medical Oncology, 2018, A289-A289

Skup
25th Biennial Congress of the European Association for Cancer Research (EACR25)

Mjesto i datum
Amsterdam, Nizozemska, 30.06.2018. - 03.07.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
p53 protein ; metastatic melanoma ; BRAF inhibitors

Sažetak
TP53 is the most frequently mutated gene in human cancer. However, in metastatic melanoma mutations of TP53 occur infrequently and p53 fails to function as a tumour suppressor. The altered expression of p53 family members, including p53/p73 isoforms, as well as of the interactions among them could affect the normal function of p53. Furthermore, somatic BRAF mutations have been found in 37%–50% of all melanomas, of which almost 90% harbour the activating V600E mutation. Although the initial response to BRAF inhibitors is highly effective, the resistant clones frequently develop, and, in treated patients disease progression is observed within 6 to 8 months. To address this, a better understanding of the genetic basis of melanoma initiation and progression is needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA