Naslov
ARTERIAL STIFFNESS AS MEASURE OF CARDIOVASCULAR RISK IN LEAN AND OBESE ADOLESCENTS AND ADOLESCENTS WITH TYPE 1 DIABETES

Autori
Putarek, Krešimir ; Banfić, Ljiljana ; Pašalić, Marijan ; Krnić, Nevena ; Špehar Uroić, Anita ; Rojnić Putarek, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Hormone Research in Paediatrics / Allen, David B - : S. Karger, 2017

ISBN
978-3-318-06237-3

Skup
10th Joint Meeting of Pediatric Endocrinology

Mjesto i datum
Washington D.C., Sjedinjene Američke Države, 14.09.2017. - 17.09.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aretrial stifness, cardiovascular risk, children, type 1 diabetes, obesity

Sažetak
Objectives: Cardiovascular disease (CVD), the major cause of death worldwide, is the end result of vascular aging and atherosclerosis, having its origins in childhood. Pediatric patients harboring classical CVD risk include obese and diabetic patients. Noninvasive methods used to evaluate vascular function include intima-media thickness (IMT) and arterial stiffness (AS) assessed with pulse wave velocity (PWV), arterial compliance (AC) and β-stiffness measurements. Methods: We analyzed parameters of AS in 68 obese adolescents (13.27 ± 2.31 yrs), 42 adolescents with type 1 diabetes (T1D) (14.95 ± 2.35 yrs) with T1D duration over 5 years and 38 controls (15.02 ± 1.94 yrs). AS was assessed using e-tracking ultrasound method (EchoTracking®, Aloka alfa-10). Height, weight, body mass index (BMI) and blood pressure (BP) were assessed in all patients. Lipid levels were measured in obese and T1D patients, while oral glucose-tolerance test (OGTT), insulin level and HOMA index were assessed in obese patients. Results: Significant difference in AS between groups was found for AC (P=0, 022) and PWS (p=0.000) with the lowest compliance and higher velocities found in T1D group. The IMT measurements did not show significant difference between groups. Multiple regression analysis in obese adolescents showed correlation of lower AC in females (p=0.041) and in patients with higher systolic BP SDS (p=0, 032). In adolescents with T1D, duration of the disease was strongest independent determinant of AS for all measures (AC, β and PWV: p=0.028 ; p=0.029 and p=0.003, respectively) followed by BMI SDS which correlated with PWV and β-index (p=0.008 and p=0.033, respectively), and HbA1c that correlated with PWV (p=0.048). Both systolic and diastolic BP correlated with lower AC (SBP SDS p<0, 001 ; DBP SDS p=0, 049) and higher PWV (SBP SDS p=0, 023, DBP SDS p=0, 048). Conclusions: Even though obese adolescents have significantly higher body weight and BMI, lower HDL cholesterol and higher BP, early vascular damage was more pronounced in adolescents with T1D. This finding may reveal the influence of hyperglycemia and its consequences on blood vessels as a major risk for cardiovascular health.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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