Naslov
Comparison between two antibiotic regimens of prophylaxis in head and neck oncological surgery

Autori
Skitarelić, Neven

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd International Meeting of Otorhinolaryngologists and Head and Neck Surgeons “ALPE ADRIA” with international participation / - , 2010, 24-24

Skup
3rd International Meeting of Otorhinolaryngologists and Head and Neck Surgeons “ALPE ADRIA” with international participation

Mjesto i datum
Malinska, Hrvatska, 16.04.2010. - 17.04.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
head and neck cancer ; surgery ; postoperative infection

Sažetak
Perioperative antibiotic prophylaxis has significantly reduced wound infection rates in clean-contaminated head and neck surgical procedures but controversy still remains regarding the optimal antibiotic regimen. In this prospective, double-blind clinical trial, 189 patients with carcinoma of the upper aerodigestive tract were randomized to receive amoxicillin-clavulanate or cefazolin intravenously up to 1 hour before surgery and at 8-hour intervals for an additional three doses. An overall wound infection rate of 22% was observed. The infection rate in patients receiving cefazolin was 24% (22/92) vs. 21% (20/97) in those receiving amoxicillin-clavulanate ; the difference was not statistically significant. Postoperative overall non-wound infection developed in 12% (22/189) patients ; the rate of infection was 9.78% (9/92) in patients receiving cefazolin vs. 13.4% (13/97) in those receiving amoxicillin-clavulanate, without a statistically significant difference between the two groups. Gram negative bacteria were more often isolated with Pseudomonas aeruginosa as the dominant species. The risk of postoperative infection was more influenced by the type of surgical procedure than by disease stage. In clean-contaminated head and neck oncologic surgery amoxicillin-clavulanate prophylaxis was at least as efficient as cefazolin. However, when taking into account the fact that beta-lactamases strains have recently been spreading, amoxicillin-clavulanate should be the logical first line of choice.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA