Naslov
Mechanisms of HBO-Induced Vascular Functional Changes in Diabetic Animal Models

Autori
Jukić, Ivana ; Mišir, Mihael ; Mihalj, Martina ; Mihaljević, Zrinka ; Unfirer, Sanela ; Kibel, Dijana ; Kibel, Aleksandar

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Yperbaric Oxygen Treatment in Research and Clinical Practice

Urednik/ci
Drenjančević, Ines

Izdavač
In Tech

Grad
Rijeka

Godina
2018

Raspon stranica
87-108

ISBN
978-1-78923-599-9

Ključne riječi
hyperbaric oxygen ; diabetes mellitus ; endothelial dysfunction ; cytochrome P450 ; nitric oxide ; arachidonic acid metabolites

Sažetak
The mechanisms by which HBO exerts its potentially beneficial effects are not completely clear. Interactions of mechanisms affecting endothelial dysfunction, NO synthesis, EETs and HETE formation, CYP expression changes, oxidative stress and antioxidant defense system changes, and multiple effects on inflammation take place that might be considered as mediating factors for the observed positive (or negative) clinical effects in diabetes mellitus (for instance in chronic diabetic wounds). Studies on vasculature in diabetic animal models can provide us with more information that can help us understand its effects on blood vessel function. This chapter discusses the most relevant studies that have assessed the potential mechanisms of HBO- induced vascular functional changes in diabetic animal models.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA