Naslov
The members of Wnt pathway SFRP1, SFRP3, and DVL1 are down regulated in testicular germ cell tumours

Autori
Fabijanović, Dora ; Žunić, Iris ; Nikuševa Martić, Tamara ; Škenderi, Faruk ; Šerman, Ljiljana ; Vranić, Semir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Virchows Archiv / - : Springer, 2016, 218-219

Skup
XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology

Mjesto i datum
Köln, Njemačka, 25.09.2016. - 29.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
Wnt signaling pathway, SFRP1, SFRP3, DVL1, DVL2, testicular tumours

Sažetak
Objective: Wnt signaling pathway components have been shown to be actively involved in normal and malignant germ cell differentiation and progression. In the present study, we aimed to explore the expression patterns of two of the Wnt pathway members, the secreted frizzled- related protein (SFRP) and Dishevelled protein family (DVL) in a subset of testicular germ cell tumours. Method: Eighty-five formalin- fixed paraffin-embedded tissue samples of the primary germ cell tumours of the testis were stained against SFRP1, SFRP3, DVL1, and DVL2 proteins using immunohistochemistry. Results: SFRP1 and SFRP3 exhibited lower expression in both seminomas and mixed/non-seminomatous tumours, compared with normal tissue (p < 0.001). SFRP3 expression was lower than SFRP1 expression within the seminoma group (p = 0.004), but not within the mixed/non- seminomatous group (p = 0.409). The majority of the tested cases (27/28, 96 %) exhibited low DVL1 protein expression (mean 9.6 %). In contrast, 20 out of 22 tested cases (91 %) exhibited a strong overexpression of DVL2 protein (mean 68.6 %, range 0–100 %). Conclusion: The secreted frizzled-related protein and dishevelled protein family members show different expression profiles in tumours, compared to normal tissue, suggesting their role in the pathogenesis of testicular germ cell tumours. Further molecular and clinical studies should confirm the relevance of our findings.

Izvorni jezik
Engleski

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