Naslov
Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer’s disease
(Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer’s disease)

Autori
Ilić, Katarina ; Mlinac Jerković, Kristina ; Jovanov Milošević, Nataša ; Šimić, Goran ; Habek, Nikola ; Bogdanović, Nenad ; Kalanj Bognar, Svjetlana

Izvornik
Journal of cellular and molecular medicine (1582-1838) 23 (2019), 2; 1602-1607

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cell-adhesion molecules ; human hippocampus ; immunohistochemistry ; neurodegeneration

Sažetak
Cell-adhesion glycoprotein neuroplastin (Np) is involved in the regulation of synaptic plasticity and balancing hippocampal excitatory/inhibitory inputs which aids in the process of associative memory formation and learning. Our recent findings show that neuroplastin expression in the adult human hippocampus is specifically associated with major hippocampal excitatory pathways and is related to neuronal calcium regulation. Here we investigated the hippocampal expression of brain- specific neuroplastin isoform (Np65), its relationship to amyloid and tau pathology in Alzheimer’s disease (AD), and potential involvement of neuroplastin in tissue response during the disease progression. Np65 expression and localization was analyzed in six human hippocampi with confirmed AD neuropathology, and six age-/gender-matched control hippocampi by imunohistochemistry. In AD cases with shorter disease duration, the Np65 immunoreactivity was significantly increased in the dentate gyrus (DG), Cornu Ammonis 2/3 (CA2/3) and subiculum, with the highest level of Np expression being located on the dendrites of granule cells and subicular pyramidal neurons. Changes in the expression of neuroplastin in AD hippocampal areas seem to be related to the progression of disease. Our study suggests that cell-adhesion protein neuroplastin is involved in tissue reorganization and is a potential molecular marker of plasticity response in the early neurodegeneration process of AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA